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Université de Fribourg

A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila*

Durmaz, Esra ; Rajpurohit, Subhash ; Betancourt, Nicolas ; Fabian, Daniel K. ; Kapun, Martin ; Schmidt, Paul ; Flatt, Thomas

In: Evolution, 2019, vol. 73, no. 9, p. 1774–1792

A fundamental aim of adaptation genomics is to identify polymorphisms that underpin variation in fitness traits. In Drosophila melanogaster, latitudinal life‐history clines exist on multiple continents and make an excellent system for dissecting the genetics of adaptation. We have previously identified numerous clinal single‐nucleotide polymorphism in insulin/insulin‐like growth factor...

Université de Fribourg

Parallel effects of the inversion In(3R)Payne on body size across the North American and Australian clines in Drosophila melanogaster

Kapun, M. ; Schmidt, C. ; Durmaz, E. ; Schmidt, P. S. ; Flatt, Thomas

In: Journal of Evolutionary Biology, 2016, vol. 29, no. 5, p. 1059–1072

Chromosomal inversions are thought to play a major role in climatic adaptation. In D. melanogaster, the cosmopolitan inversion In(3R)Payne exhibits latitudinal clines on multiple continents. As many fitness traits show similar clines, it is tempting to hypothesize that In(3R)P underlies observed clinal patterns for some of these traits. In support of this idea, previous work in Australian...

Université de Fribourg

Genomic evidence for adaptive inversion clines in Drosophila melanogaster

Kapun, Martin ; Fabian, Daniel K. ; Goudet, Jérôme ; Flatt, Thomas

In: Molecular Biology and Evolution, 2016, vol. 33, no. 5, p. 1317–1336

Clines in chromosomal inversion polymorphisms—presumably driven by climatic gradients—are common but there is surprisingly little evidence for selection acting on them. Here we address this long-standing issue in Drosophila melanogaster by using diagnostic single nucleotide polymorphism (SNP) markers to estimate inversion frequencies from 28 whole-genome Pool-seq samples collected from 10...

Université de Fribourg

Spatially varying selection shapes life history clines among populations of Drosophila melanogaster from sub-Saharan Africa

Fabian, D. K. ; Lack, J. B. ; Mathur, V. ; Schlötterer, C. ; Schmidt, P. S. ; Pool, J. E. ; Flatt, Thomas

In: Journal of Evolutionary Biology, 2015, vol. 28, no. 4, p. 826–840

Clines in life history traits, presumably driven by spatially varying selection, are widespread. Major latitudinal clines have been observed, for example, in Drosophila melanogaster, an ancestrally tropical insect from Africa that has colonized temperate habitats on multiple continents. Yet, how geographic factors other than latitude, such as altitude or longitude, affect life history in this...