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In Vivo Longitudinal 1H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1T

Cudalbu, Cristina ; Craveiro, Melanie ; Mlynárik, Vladimir ; Bremer, Juliane ; Aguzzi, Adriano ; Gruetter, Rolf

In: Neurochemical Research, 2015, vol. 40, no. 12, p. 2639-2646

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons

Zheng, Lu ; Bernard-Marissal, Nathalie ; Moullan, Norman ; D'Amico, Davide ; Auwerx, Johan ; Moore, Darren J. ; Knott, Graham ; Aebischer, Patrick ; Schneider, Bernard L.

In: Human Molecular Genetics, 2017, vol. 26, no. 3, p. 582-598

Effects of Hypocretin/Orexin and Major Transmitters of Arousal on Fast Spiking Neurons in Mouse Cortical Layer 6B

Wenger Combremont, Anne-Laure ; Bayer, Laurence ; Dupré, Anouk ; Mühlethaler, Michel ; Serafin, Mauro

In: Cerebral Cortex, 2016, vol. 26, no. 8, p. 3553-3562

Integrity of cortical perineuronal nets influences corticospinal tract plasticity after spinal cord injury

Orlando, C. ; Raineteau, O.

In: Brain Structure and Function, 2015, vol. 220, no. 2, p. 1077-1091

Optogenetic stimulation of basal forebrain parvalbumin neurons activates the default mode network and associated behaviors

Lozano-Montes, Laura ; Dimanico, Marta ; Mazloum, Reza ; Li, Wenxue ; Nair, Jayakrishnan ; Kintscher, Michael ; Schneggenburger, Ralf ; Harvey, Michael ; Rainer, Gregor

In: Cell Reports, 2020, vol. 33, no. 6, p. 108359

Activation of the basal forebrain (BF) has been associated with increased attention, arousal, and a heightened cortical representation of the external world. In addition, BF has been implicated in the regulation of the default mode network (DMN) and associated behaviors. Here, we provide causal evidence for a role of BF in DMN regulation, highlighting a prominent role of parvalbumin (PV)...

Parvalbumin-deficiency accelerates the age-dependent ROS production in Pvalb neurons in vivo: link to neurodevelopmental disorders

Janickova, Lucia ; Schwaller, Beat

In: Frontiers in Cellular Neuroscience, 2020, vol. 14, p. -

In neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD) and schizophrenia, impairment/malfunctioning of a subpopulation of interneurons expressing the calcium-binding protein parvalbumin (PV) –here termed Pvalb neurons– has gradually emerged as a possible cause. These neurons may represent a hub or point-of-convergence in the etiology of NDD. Increased oxidative...

Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes

Janickova, Lucia ; Rechberger, Karin Farah ; Wey, Lucas ; Schwaller, Beat

In: Molecular Autism, 2020, vol. 11, no. 1, p. 47

In fast firing, parvalbumin (PV)-expressing (Pvalb) interneurons, PV acts as an intracellular Ca2+ signal modulator with slow-onset kinetics. In Purkinje cells of PV−/− mice, adaptive/homeostatic mechanisms lead to an increase in mitochondria, organelles equally capable of delayed Ca2+ sequestering/buffering. An inverse regulation of PV and mitochondria likewise operates in cell model...

Inducible and reversible silencing of the Pvalb gene in mice: An in vitro and in vivo study

Filice, Federica ; Blum, Walter ; Lauber, Emanuel ; Schwaller, Beat

In: European Journal of Neuroscience, 2019, vol. 50, no. 4, p. 2694–2706

Inducible and reversible regulation of gene expression is a powerful approach for unraveling gene functions. Here, we describe the generation of a system to efficiently downregulate in a reversible and inducible manner the Pvalb gene coding for the calcium‐binding protein parvalbumin (PV) in mice. We made use of an IPTG‐inducible short hairpin RNA to activate Pvalb transcript knockdown...

Parvalbumin expression in oligodendrocyte-like CG4 cells causes a reduction in mitochondrial volume, attenuation in reactive oxygen species production and a decrease in cell processes’ length and branching

Lichvarova, Lucia ; Blum, Walter ; Schwaller, Beat ; Szabolcsi, Viktoria

In: Scientific Reports, 2019, vol. 9, no. 1, p. 10603

Forebrain glial cells - ependymal cells and astrocytes -acquire upon injury- a “reactive” phenotype associated with parvalbumin (PV) upregulation. Since free radicals, e.g. reactive oxygen species (ROS) play a role in the pathogenesis of multiple sclerosis, and that PV-upregulation in glial cells is inversely correlated with the level of oxidative stress, we hypothesized that...

Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

Belaunzaran, Osiris Marroquin ; Cordero, Maria Isabel ; Setola, Veronica ; Bianchi, Siro ; Galli, Carmela ; Bouche, Nicolas ; Mlynarik, Vladimir ; Gruetter, Rolf ; Sandi, Carmen ; Bensadoun, Jean-Charles ; Molinari, Maurizio ; Aebischer, Patrick

In: Plos one, 2011, vol. 6, no. 4, p. e18268

Background: Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional limitations such as inadequate pharmacokinetics and tissue accessibility are the current principal disadvantages for broadening their use in clinic. Methodology and Principal Findings: We report a novel method for the long-term ...