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A comprehensive analysis of gene expression profiles in distal parts of the mouse renal tubule

Pradervand, Sylvain ; Zuber Mercier, Annie ; Centeno, Gabriel ; Bonny, Olivier ; Firsov, Dmitri

In: Pflügers Archiv - European Journal of Physiology, 2010, vol. 460, no. 6, p. 925-952

αENaC mediated lithium absorption promotes nephrogenic diabetes insipidus

Mønster Christensen, Birgitte ; Mercier Zuber, Annie ; Loffing, Johannes ; Stehle, Jean-Christophe ; Deen, Peter M.T. ; Rossier, Bernard C. ; Hummler, Edith

In: Journal of the American Society of Nephrology, 2010, vol. 21, p. -

Lithium-induced nephrogenic diabetes insipidus (NDI) is accompanied by polyuria, downregulation of aquaporin 2 (AQP2), and cellular remodeling of the collecting duct (CD). The amiloride-sensitive epithelial sodium channel (ENaC) is a likely candidate for lithium entry. Here, we subjected transgenic mice lacking αENaC specifically in the CD (knockout [KO] mice) and littermate controls to chronic...