In: Frontiers in Physiology, 2017, vol. 8, p. -
The mitochondrial arginase type II (Arg-II) has been shown to interact with ribosomal protein S6 kinase 1 (S6K1) and mitochondrial p66Shc and to promote cell senescence, apoptosis and inflammation under pathological conditions. However, the impact of Arg-II on organismal lifespan is not known. In this study, we demonstrate a significant lifespan extension in mice with Arg-II gene deficiency...
- F., and Yang, Z. (2017)....
- P., Yang,
Z....
- P., Yang, Z....
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In: Cardiovascular Research, 2002, vol. 53, no. 1, p. 227-231
- Cardiovascular Research 53 (2002) 227–231
www.elsevier.com / locate / cardiores
Felodipine inhibits nuclear translocation of p42 / 44 mitogen-activated
protein kinase and human smooth muscle cell growth
Zhihong Yang a , Anna Madinova b , Toshiyuki Kozai c , Hana Joch c , Ueli Aebi b ,
¨
Thomas F....
- Max Cloetta Foundation (Zhihong Yang)....
- Circ Res 1999;85:877–879.
[2] Yang Z, Luscher TF....
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In: Cardiovascular Research, 2013, vol. 97, no. 1, p. 8-9
- Zhihong Yang*
´
Laboratory of Vascular Biology, Division of Physiology, Department of Medicine, Faculty of Science, University of Fribourg, Rue du Musee 5, Fribourg CH-1700, Switzerland
Online publish-ahead-of-print 2 November 2012
This editorial refers to ‘Importance of endothelial NF-kB
signaling in vascular remodelling and aortic aneurysm formation’ by T....
- Yang Z, Ming XF....
- Barandier C, Montani JP, Yang Z....
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In: Cardiovascular Research, 2011, vol. 89, no. 3, p. 485-486
- Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ et al....
- Barandier C, Montani JP, Yang Z....
- Yang Z, Ming XF....
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In: Frontiers in Physiology, 2016, vol. 7, p. -
Obesity is associated with development and progression of chronic kidney disease (CKD). Recent evidence demonstrates that enhanced levels of the L- arginine:ureahydrolase, including the two isoenzymes arginase-I (Arg-I) and arginase- II (Arg-II) in vascular endothelial cells promote uncoupling of endothelial nitric oxide synthase (eNOS), leading to increased superoxide radical anion and...
- P., Yang, Z., et al. (2015)....
- P., Yang, Z., and Ming, X....
- P., Yang, Z., and Ming, X....
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In: Frontiers in Inflammation, 2013, vol. 4, p. 149
Oxidative stress and inflammation in the vascular wall are essential mechanisms of atherosclerosis and vascular dysfunctions associated with risk factors such as metabolic diseases, aging, hypertension, etc. Evidence has been provided that activation of the vascular endothelial cells in the presence of the risk factors promotes oxidative stress and vascular inflammatory responses, leading to...
- H., Yang, W....
- Yang, Z., and Ming, X....
- Copyright © 2013 Yang and Ming ....
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In: Cardiovascular Research, 2013, vol. 97, no. 1, p. 8-9
It has been established in the past few decades that the vascular endothelium, the monolayer of cells covering the inner surface of the vessel wall, functions as a master regulator to maintain the physiological integrity of vascular function and structure by actively releasing numerous vasoactive hormones that control smooth muscle cell contraction and proliferation and inflammatory cell adhesion...
- Zhihong Yang*
´
Laboratory of Vascular Biology, Division of Physiology, Department of Medicine, Faculty of Science, University of Fribourg, Rue du Musee 5, Fribourg CH-1700, Switzerland
Online publish-ahead-of-print 2 November 2012
This editorial refers to ‘Importance of endothelial NF-kB
signaling in vascular remodelling and aortic aneurysm formation’ by T....
- Yang Z, Ming XF....
- Barandier C, Montani JP, Yang Z....
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In: Aging Cell, 2012, p. -
Augmented activities of both arginase and S6K1 are involved in endothelial dysfunction in aging. This study was to investigate whether or not there is a crosstalk between arginase and S6K1 in endothelial inflammation and aging in senescent human umbilical vein endothelial cells and in aging mouse models. We show increased arginase-II (Arg-II) expression/activity in senescent endothelial cells....
- Rajapakse, Jean-Pierre Montani, Xiu-Fen Ming and Zhihong Yang
Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Fribourg, Switzerland
Summary
Augmented activities of both arginase and S6K1 are involved in endothelial dysfunction in aging....
- https://doc.rero.ch
Correspondence Zhihong Yang, MD and Xiu-Fen Ming, Department of Medicine, Division of Phys´e iology, University of Fribourg, Chemin du Muse 5, CH-1700 Fribourg, Switzerland....
- Rajapakse, Jean-Pierre Montani, Xiu-Fen Ming†, Zhihong Yang† Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Switzerland Supporting Information listing Supplementary figure legends Fig....
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In: Oxidative Medicine & Cellular Longevity, 2009, vol. 2, no. 3, p. 172-175
Elevated cellular levels of protein O-linked β-N-acetylglucosamine (O-GlcNAc) through hexosamine biosynthesis pathway (HBP) are suggested to contribute to cardiovascular adverse effects under chronic hyperglycemic condition associated with oxidative stress and inflammation. Conversely, enhancing O- GlcNAc levels have also been demonstrated being protective against myocardial ...
- Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, et al....
- Rajapakse AG, Ming XF, Carvas JM, Yang Z....
- Yang Z, Ming XF....
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In: Journal of Vascular Research, 2006, vol. 43, no. 4, p. 338-346
The remarkable patency of internal mammary artery (MA) grafts compared to saphenous vein (SV) grafts has been related to different biological properties of the two blood vessels. We examined whether proliferation and apoptosis of vascular smooth muscle cells (VSMC) from human coronary artery bypass vessels differ according to patency rates. Methods and Results: Proliferation rates to serum...
- Different Vascular Smooth Muscle Cell Apoptosis in the Human Internal Mammary Artery and the Saphenous Vein
Implications for Bypass Graft Disease
Karin Frischknecht a, b Helen Greutert a, b Christian Weisshaupt a, b Mathias Kaspar a–c Zhihong Yang d Thomas F....
- Hemmings, PhD (Friedrich Miescher Institute Basel, Switzerland) and Zhihong Yang, MD (University of Fribourg, Switzerland) [12, 13]....
- J Clin Endocrinol Metab 1974;39:512–521. 9 Tanner FC, Yang ZY, Duckers E, Gordon D, Nabel GJ, Nabel EG: Expression of cyclindependent kinase inhibitors in vascular disease....
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