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Université de Fribourg

Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging

Yepuri, Gautham ; Velagapudi, Srividya ; Xiong, Yuyan ; Rajapakse, Angana G. ; Montani, Jean-Pierre ; Ming, Xiu-Fen ; Yang, Zhihong

In: Aging Cell, 2012, p. -

Augmented activities of both arginase and S6K1 are involved in endothelial dysfunction in aging. This study was to investigate whether or not there is a crosstalk between arginase and S6K1 in endothelial inflammation and aging in senescent human umbilical vein endothelial cells and in aging mouse models. We show increased arginase-II (Arg-II) expression/activity in senescent endothelial cells....

  • We are grateful to Jean Ruffieux and Zongsong Wu for technical assistance....
Université de Fribourg

Arginase iI promotes macrophage inflammatory responses through mitochondrial reactive oxygen species, contributing to insulin resistance and atherogenesis

Ming, Xiu‐Fen ; Rajapakse, Angana G. ; Yepuri, Gautham ; Xiong, Yuyan ; Carvas, João M. ; Ruffieux, Jean ; Scerri, Isabelle ; Wu, Zongsong ; Popp, Katja ; Li, Jianhui ; Sartori, Claudio ; Scherrer, Urs ; Kwak, Brenda R. ; Montani, Jean‐Pierre ; Yang, Zhihong

In: Journal of the American Heart Association, 2012, p. -

Background Macrophage‐mediated chronic inflammation is mechanistically linked to insulin resistance and atherosclerosis. Although arginase I is considered antiinflammatory, the role of arginase II (Arg‐II) in macrophage function remains elusive. This study characterizes the role of Arg‐II in macrophage inflammatory responses and its impact on obesity‐linked type II...

  • Carvas, MSc; Jean Ruffieux, BSc; a Isabelle Scerri, BSc; Zongsong Wu, MSc; Katja Popp, PhD; Jianhui Li, MD; Claudio Sartori, MD; Urs Scherrer, MD; Brenda R....
  • Wu were supported by the Chinese Scholarship Council....
  • Kepka-Lenhart D, Mistry SK, Wu G, Morris SM Jr....
2 results 1