Université de Fribourg

Circadian rhythms govern cardiac repolarization and arrhythmogenesis

Jeyaraj, Darwin ; Haldar, Saptarsi M. ; Wan, Xiaoping ; McCauley, Mark D. ; Ripperger, Jürgen A. ; Hu, Kun ; Lu, Yuan ; Eapen, Betty L. ; Sharma, Nikunj ; Ficker, Eckhard ; Cutler, Michael J. ; Gulick, James ; Sanbe, Atsushi ; Robbins, Jeffrey ; Demolombe, Sophie ; Kondratov, Roman V. ; Shea, Steven A. ; Albrecht, Urs ; Wehrens, Xander H. T. ; Rosenbaum, David S. ; Jain, Mukesh K.

In: Nature, 2012, vol. 483, p. 96-99

Sudden cardiac death exhibits diurnal variation in both acquired and hereditary forms of heart disease, but the molecular basis of this variation is unknown. A common mechanism that underlies susceptibility to ventricular arrhythmias is abnormalities in the duration (for example, short or long QT syndromes and heart failure) or pattern (for example, Brugada’s syndrome)6 of myocardial...

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1 Wehrens, Xander H. T.