Université de Fribourg

The Caenorhabditis elegans LET-418/Mi2 plays a conserved role in lifespan regulation

Vaux, Véronique De ; Pfefferli, Catherine ; Passannante, Myriam ; Belhaj, Khaoula ; Essen, Alina von ; Sprecher, Simon G. ; Müller, Fritz ; Wicky, Chantal

In: Aging Cell, 2013, p. –

The evolutionarily conserved nucleosome-remodeling protein Mi2 is involved in transcriptional repression during development in various model systems, plays a role in embryonic patterning and germ line development, and participates in DNA repair and cell cycle progression. It is the catalytic subunit of the nucleosome remodeling and histone deacetylase (NuRD) complex, a key determinant of...

Université de Fribourg

Role of proneural genes in the formation of the larval olfactory organ of Drosophila

Grillenzoni, Nicola ; Vaux, Véronique de ; Meuwly, Jocelyne ; Vuichard, Séverine ; Jarman, Andrew ; Holohan, Eimear ; Gendre, Nanaë ; Stocker, Reinhard F.

In: Development Genes and Evolution, 2007, vol. 217, no. 3, p. 209-219

In this paper, we address the role of proneural genes in the formation of the dorsal organ in the Drosophila larva. This organ is an intricate compound comprising the multineuronal dome—the exclusive larval olfactory organ—and a number of mostly gustatory sensilla. We first determine the numbers of neurons and of the different types of accessory cells in the dorsal organ. From...