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GLUT2, glucose sensing and glucose homeostasis

Thorens, Bernard

In: Diabetologia, 2015, vol. 58, no. 2, p. 221-232

Ins1 Cre knock-in mice for beta cell-specific gene recombination

Thorens, Bernard ; Tarussio, David ; Maestro, Miguel ; Rovira, Meritxell ; Heikkilä, Eija ; Ferrer, Jorge

In: Diabetologia, 2015, vol. 58, no. 3, p. 558-565

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

Winnik, Stephan ; Gaul, Daniel ; Preitner, Frédéric ; Lohmann, Christine ; Weber, Julien ; Miranda, Melroy ; Liu, Yilei ; van Tits, Lambertus ; Mateos, José ; Brokopp, Chad ; Auwerx, Johan ; Thorens, Bernard ; Lüscher, Thomas ; Matter, Christian

In: Basic Research in Cardiology, 2014, vol. 109, no. 1, p. 1-15

The SLC2 family of facilitated hexose and polyol transporters

Uldry, Marc ; Thorens, Bernard

In: Pflügers Archiv, 2004, vol. 447, no. 5, p. 480-489

The SLC2 family of facilitated hexose and polyol transporters

Uldry, Marc ; Thorens, Bernard

In: Pflügers Archiv, 2004, vol. 448, no. 2, p. 259-260

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass

Mitchell, Ryan K. ; Mondragon, Angeles ; Chen, Lingling ; Mcginty, James A. ; French, Paul M. ; Ferrer, Jorge ; Thorens, Bernard ; Hodson, David J. ; Rutter, Guy A. ; Da Silva Xavier, Gabriela

In: Human Molecular Genetics, 2015, vol. 24, no. 5, p. 1390-1399

Hypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion

Lamy, Christophe M. ; Sanno, Hitomi ; Labouèbe, Gwenaël ; Picard, Alexandre ; Magnan, Christophe ; Chatton, Jean-Yves ; Thorens, Bernard

In: Cell Metabolism, 2014, vol. 19, no. 3, p. 527–538

Glucose-sensing neurons in the brainstem participate in the regulation of energy homeostasis but have been poorly characterized because of the lack of specific markers to identify them. Here we show that GLUT2-expressing neurons of the nucleus of the tractus solitarius form a distinct population of hypoglycemia-activated neurons. Their response to low glucose is mediated by reduced intracellular...

PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance

Becattini, Barbara ; Marone, Romina ; Zani, Fabio ; Arsenijevic, Denis ; Seydoux, Josiane ; Montani, Jean-Pierre ; Dulloo, Abdul G. ; Thorens, Bernard ; Preitner, Frédéric ; Wymann, Matthias P. ; Solinas, Giovanni

In: Proceedings of the National Academy of Sciences of the United States of America, 2011, vol. 108, no. 42, p. E854-E863

Obesity is associated with a chronic low-grade inflammation, and specific antiinflammatory interventions may be beneficial for the treatment of type 2 diabetes and other obesity-related diseases. The lipid kinase PI3Kγ is a central proinflammatory signal transducer that plays a major role in leukocyte chemotaxis, mast cell degranulation, and endothelial cell activation. It was also reported that...