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Suppression of intratumoral CCL22 by type I interferon inhibits migration of regulatory T cells and blocks cancer progression

Anz, David ; Rapp, Moritz ; Eiber, Stephan ; Koelzer, Viktor H ; Thaler, Raffael ; Haubner, Sascha ; Knott, Max ; Nagel, Sarah ; Golic, Michaela ; Wiedemann, Gabriela M ; Bauernfeind, Franz ; Wurzenberger, Cornelia ; Hornung, Veit ; Scholz, Christoph ; Mayr, Doris ; Rothenfusser, Simon ; Endres, Stefan ; Bourquin, Carole

In: Cancer Research, 2015, vol. 75, no. 21, p. 4483-4493

The chemokine CCL22 is abundantly expressed in many types of cancer and is instrumental for intratumoral recruitment of regulatory T cells (Treg), an important subset of immunosuppressive and tumor-promoting lymphocytes. In this study, we offer evidence for a generalized strategy to blunt Treg activity that can limit immune escape and promote tumor rejection. Activation of innate immunity with...