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Selective Bispecific T Cell Recruiting Antibody and Antitumor Activity of Adoptive T Cell Transfer

Kobold, Sebastian ; Steffen, Julius ; Chaloupka, Michael ; Grassmann, Simon ; Henkel, Jonas ; Castoldi, Raffaella ; Zeng, Yi ; Chmielewski, Markus ; Schmollinger, Jan C. ; Schnurr, Max ; Rothenfußer, Simon ; Schendel, Dolores J. ; Abken, Hinrich ; Sustmann, Claudio ; Niederfellner, Gerhard ; Klein, Christian ; Bourquin, Carole ; Endres, Stefan

In: Journal Of The National Cancer Institute, 2014, vol. 107, no. 1, p. -

Selective bispecific T cell recruiting antibody and antitumor activity of adoptive T cell transfer

Kobold, Sebastian ; Steffen, Julius ; Chaloupka, Michael ; Grassmann, Simon ; Henkel, Jonas ; Castoldi, Raffaella ; Zeng, Yi ; Chmielewski, Markus ; Schmollinger, Jan C. ; Schnurr, Max ; Rothenfußer, Simon ; Schendel, Dolores J. ; Abken, Hinrich ; Sustmann, Claudio ; Niederfellner, Gerhard ; Klein, Christian ; Bourquin, Carole ; Endres, Stefan

In: Journal of the National Cancer Institute, 2014, vol. 107, no. 1, p. dju364

Background: One bottleneck for adoptive T cell therapy (ACT) is recruitment of T cells into tumors. We hypothesized that combining tumor-specific T cells, modified with a marker antigen and a bispecific antibody (BiAb) that selectively recognizes transduced T cells and tumor cells would improve T cell recruitment to tumors and enhance therapeutic efficacy.Methods: SV40 T antigen–specific T...

CD103 is a hallmark of tumor-infiltrating regulatory T cells

Anz, David ; Mueller, Wolfgang ; Golic, Michaela ; Kunz, Wolfgang G. ; Rapp, Moritz ; Koelzer, Viktor H. ; Ellermeier, Jonathan ; Ellwart, Joachim W. ; Schnurr, Max ; Bourquin, Carole ; Endres, Stefan

In: International Journal of Cancer, 2012, vol. 129, no. 10, p. 2417–2426

Regulatory T cells (Treg) mediate tolerance towards self-antigens by suppression of innate and adaptive immunity. In cancer patients, tumor-infiltrating FoxP3+ Treg suppress local anti-tumor immune responses and are often associated with poor prognosis. Markers that are selectively expressed on tumor-infiltrating Treg may serve as targets for immunotherapy of cancer. Here we show that CD103, an...