In: CNS Neuroscience & Therapeutics, 2019, p. cns.13213
In spinal cord injured adult mammals, neutralizing the neurite growth inhibitor Nogo‐A with antibodies promotes axonal regeneration and functional recovery, although axonal regeneration is limited in length. Neurotrophic factors such as BDNF stimulate neurite outgrowth and protect axotomized neurons. Can the effects obtained by neutralizing Nogo‐A, inducing an environment favorable for...
- On the quantitative point of view
ORCID
Eric M....
- Freund P, Schmidlin E, Wannier T, et al....
- Freund P, Wannier T, Schmidlin E, et al....
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In: European Journal of Neuroscience, 2019, p. -
Non-invasive reversible perturbation techniques of brain output such as continuous theta burst stimulation (cTBS), commonly used to modulate cortical excitability in humans, allow investigation of possible roles in functional recovery played by distinct intact cortical areas following stroke. To evaluate the potential of cTBS, the behavioural effects of this non-invasive transient...
- Rouiller
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Eric Schmidlin
Section of Medicine, Department of
Neurosciences and Movement
Sciences, Faculty of Science and
Medicine, University of Fribourg, Fribourg,
Switzerland
Correspondence
Eric Schmidlin, Section of Medicine,
Department of Neurosciences and
Movement Sciences, Faculty of Science
and Medicine, University of Fribourg,
Chemin du Musée 5, CH‐1700 Fribourg,
Switzerland....
- ORCID
Eric M....
- Rouiller
Eric Schmidlin
13
https://orcid.org/0000-0003-1355-6019
https://orcid.org/0000-0001-8638-2369
https://doc.rero.ch
R E F E R E NC E S
the dorsolateral prefrontal cortex and the Pre‐SMA alter drift rate
and response thresholds respectively during perceptual decision‐
making....
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In: European Journal of Neuroscience, 2018, vol. 48, no. 4, p. 2050–2070
- Schwab7 | Eric M....
- Schmidlin, Dr....
- ORCID
Eric M....
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In: Experimental Brain Research, 2012, vol. 223, no. 3, p. 321-340
- Schwab • Abderaouf Belhaj-Saif
Eric M....
- Rouiller et al. 1998; Liu and
Rouiller 1999; Schmidlin et al. 2004; Freund et al. 2006,
2009)....
- Schmidlin et al. 2004, 2005)....
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In: Neuroscience, 2017, vol. 357, p. 303-324
From a case study, we describe the impact of unilateral lesion of the hand area in the primary motor cortex (M1) on manual dexterity and the role of the intact contralesional M1 in long-term functional recovery. An adult macaque monkey performed two manual dexterity tasks: (i) “modified Brinkman board” task, assessed simple precision grip versus complex precision grip, the latter involved a...
- ROLE OF PRIMARY MOTOR CORTEX IN THE CONTROL OF MANUAL
DEXTERITY ASSESSED VIA SEQUENTIAL BILATERAL LESION IN THE
ADULT MACAQUE MONKEY: A CASE STUDY
´
JULIE SAVIDAN, MELANIE KAESER,
ABDERRAOUF BELHAJ-SAI¨F, ERIC SCHMIDLIN AND
ERIC M....
- Eric Schmidlin
participated in the experimental design (including ICMS
and MRI acquisition), performed the surgery and
lesions....
- Eric M....
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In: Experimental Brain Research, 2012, vol. 223, no. 3, p. 321-340
Following unilateral lesion of the primary motor cortex, the reorganization of callosal projections from the intact hemisphere to the ipsilesional premotor cortex (PM) was investigated in 7 adult macaque monkeys, in absence of treatment (control; n = 4) or treated with function blocking antibodies against the neurite growth inhibitory protein Nogo-A (n = 3). After functional recovery, though...
- Schwab • Abderaouf Belhaj-Saif
Eric M....
- Rouiller et al. 1998; Liu and
Rouiller 1999; Schmidlin et al. 2004; Freund et al. 2006,
2009)....
- Schmidlin et al. 2004, 2005)....
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In: Journal of Biomedical Optics, 2011, vol. 16, no. 09, p. 096011
The nonhuman primate model is suitable to study mechanisms of functional recovery following lesion of the cerebral cortex (motor cortex), on which therapeutic strategies can be tested. To interpret behavioral data (time course and extent of functional recovery), it is crucial to monitor the properties of the experimental cortical lesion, induced by infusion of the excitotoxin ibotenic acid. In...
- Follow-up of cortical activity and structure after lesion with laser speckle imaging and magnetic resonance imaging in nonhuman primates
J¨ rn Peuser o Abderraouf Belhaj-Saif Adjia Hamadjida Eric Schmidlin Anne-Dominique Gindrat Andreas Charles V¨ lker o Pavel Zakharov Henri-Marcel Hoogewoud Eric M....
- Schmidlin, T....
- Schmidlin, T....
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In: BMC Neuroscience, 2009, vol. 10, p. 155
Background Polymicrogyria is a malformation of the cerebral cortex often resulting in epilepsy or mental retardation. It remains unclear whether this pathology affects the structure and function of the corticospinal (CS) system. The anatomy and histology of the brain of one macaque monkey exhibiting a spontaneous polymicrogyria (PMG monkey) were examined and compared to the brain of normal...
- BMC Neuroscience
Research article
BioMed Central
Open Access
A case of polymicrogyria in macaque monkey: impact on anatomy and function of the motor system
Eric Schmidlin*†1, Christophe Jouffrais†1,2, Patrick Freund1, Patrizia Wannier-Morino1, Marie-Laure Beaud1, Eric M Rouiller1 and Thierry Wannier1
Address: 1Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Chemin du Musée 5, CH-1700 Fribourg, Switzerland and 2IRIT, Université de Toulouse and CNRS, 133 route de Narbonne, 31062 Toulouse cedex 9, France Email: Eric Schmidlin* - eric.schmidlin@unifr.ch; Christophe Jouffrais - jouffrai@irit.fr; Patrick Freund - p.freund@ion.ucl.ac.uk; Patrizia Wannier-Morino - patrizia.wannier@unifr.ch; Marie-Laure Beaud - marie-laure.beaud@unifr.ch; Eric M Rouiller - eric.rouiller@unifr.ch; Thierry Wannier - thierry.wannier@unifr.ch * Corresponding author †Equal contributors
Published: 23 December 2009 BMC Neuroscience 2009, 10:155 doi:10.1186/1471-2202-10-155
Received: 10 February 2009 Accepted: 23 December 2009
This article is available from: http://www.biomedcentral.com/1471-2202/10/155 © 2009 Schmidlin et al; licensee BioMed Central Ltd....
- Schmidlin E, Wannier T, Bloch J, Belhaj-Saif A, Wyss AF, Rouiller EM: Reduction of the hand representation in the ipsilateral primary motor cortex following unilateral section of the corticospinal tract at cervical level in monkeys....
- Freund P, Wannier T, Schmidlin E, Bloch J, Mir A, Schwab ME, Rouiller EM: Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey....
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In: European Journal of Neuroscience, 2009, vol. 29, no. 5, p. 983 - 996
In rodents and nonhuman primates subjected to spinal cord lesion, neutralizing the neurite growth inhibitor Nogo-A has been shown to promote regenerative axonal sprouting and functional recovery. The goal of the present report was to re-examine the data on the recovery of the primate manual dexterity using refined behavioral analyses and further statistical assessments, representing secondary...
- Anti-Nogo-A antibody treatment promotes recovery of manual dexterity after unilateral cervical lesion in adult primates – re-examination and extension of behavioral data
Patrick Freund,1,* Eric Schmidlin,1,* Thierry Wannier,1,2,* Jocelyne Bloch,3 Anis Mir,4 Martin E....
- Schwab2 and Eric M....
- As previously reported in detail (Schmidlin et al., 2004, 2005; Wannier et al., 2005; Freund et al., 2006a, 2007)....
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In: Brain Research, 2004, vol. 1017, p. 172-182
After a sub-total hemisection of the cervical cord at level C7/C8 in monkeys, a paralysis of the homolateral hand is rapidly followed by an incomplete recovery of manual dexterity, reaching a plateau after about 40–50 days, whose extent appears related to the size of the lesion. During a few days after the lesion, the hand representation in the contralateral motor cortex disappeared, replaced...
- Published in Brain Research 1017(1-2): 172-183, 2004
Progressive plastic changes in the hand representation of the primary motor cortex parallels incomplete recovery from a unilateral section of the corticospinal tract at cervical level in monkeys Eric Schmidlin1,*, Thierry Wannier1,2,*, Jocelyne Bloch3 and Eric M....
- Eric M....
- Schmidlin, J....
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