Refine my results

the clock genes Period 2 and Cryptochrome 2 differentially balance bone formation

Maronde, Erik ; Schilling, Arndt F. ; Seitz, Sebastian ; Schinke, Thorsten ; Schmutz, Isabelle ; Horst, Gijsbertus van der ; Amling, Michael ; Albrecht, Urs

In: PLoS One, 2010, vol. 5, no. 7, p. e11527

Background: Clock genes and their protein products regulate circadian rhythms in mammals but have also been implicated in various physiological processes, including bone formation. Osteoblasts build new mineralized bone whereas osteoclasts degrade it thereby balancing bone formation. To evaluate the contribution of clock components in this process, we investigated mice mutant in clock genes for a...