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Hypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion

Lamy, Christophe M. ; Sanno, Hitomi ; Labouèbe, Gwenaël ; Picard, Alexandre ; Magnan, Christophe ; Chatton, Jean-Yves ; Thorens, Bernard

In: Cell Metabolism, 2014, vol. 19, no. 3, p. 527–538

Glucose-sensing neurons in the brainstem participate in the regulation of energy homeostasis but have been poorly characterized because of the lack of specific markers to identify them. Here we show that GLUT2-expressing neurons of the nucleus of the tractus solitarius form a distinct population of hypoglycemia-activated neurons. Their response to low glucose is mediated by reduced intracellular...