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Structural basis for the molecular evolution of SRP-GTPase activation by protein

Bange, Gert ; Kümmerer, Nico ; Grudnik, Przemyslaw ; Lindner, Robert ; Petzold, Georg ; Kressler, Dieter ; Hurt, Ed ; Wild, Klemens ; Sinning, Irmgard

In: Nature Structural & Molecular Biology, 2011, vol. 18, p. 1376–1380

Small G proteins have key roles in signal transduction pathways. They are switched from the signaling 'on' to the non-signaling 'off' state when GTPase-activating proteins (GAPs) provide a catalytic residue. The ancient signal recognition particle (SRP)-type GTPases form GTP-dependent homo- and heterodimers and deviate from the canonical switch paradigm in that no GAPs have been identified. Here...