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Intestinal carriage of extended-spectrum beta-lactamase–producing Enterobacteriaceae at admission in a Portuguese hospital

Aires-de-Sousa, Marta ; Lopes, Elizeth ; Gonçalves, Maria Luísa ; Pereira, Ana Luísa ; Machado e Costa, Augusto ; Lencastre, Hermínia de ; Poirel, Laurent

In: European Journal of Clinical Microbiology & Infectious Diseases, 2019, p. -

To evaluate the prevalence of extended-spectrum β-lactamase (ESBL)–producing Enterobacteriaceae fecal carriers at admission in a Portuguese hospital and to determine the epidemiology and antimicrobial resistance patterns of ESBL-producing isolates. During a 2-month period, rectal swabs were collected at hospital admission from 151 at-risk patients. In addition, 48 rectal swabs were...

Epidemiology of Carbapenemase-Producing Klebsiella pneumoniae in a Hospital, Portugal

Aires-de-Sousa, Marta ; Ortiz de la Rosa, José Manuel ; Gonçalves, Maria Luísa ; Pereira, Ana Luísa ; Nordmann, Patrice ; Poirel, Laurent

In: Emerging Infectious Diseases, 2019, vol. 25, no. 9, p. 1632–1638

We aimed to provide updated epidemiologic data on carbapenem-resistant Klebsiella pneumoniae in Portugal by characterizing all isolates (N = 46) recovered during 2013– 2018 in a 123-bed hospital in Lisbon. We identified blaKPC-3 (n = 36), blaOXA-181 (n = 9), and blaGES-5 (n = 8) carbapenemase genes and observed co-occurrence of blaKPC-3 and blaGES-5 in 7 isolates. A single GES-5–producing...

Plant pathogenesis-related proteins of the cacao fungal pathogen Moniliophthora perniciosa differ in their lipid-binding specificities

Darwiche, Rabih ; El Atab, Ola ; Baroni, Renata Moro ; Teixeira, Paulo J. P. L. ; Mondego, Jorge M. C. ; Pereira, Gonçalo A. G. ; Schneiter, Roger

In: Journal of Biological Chemistry, 2017, p. jbc.M117.811398

Moniliophthora perniciosa is the causative agent of witches' broom disease, which devastates cacao cultures in South America. This pathogenic fungus infects meristematic tissues and derives nutrients from the plant apoplast during an unusually long-lasting biotrophic stage. In order to survive, the fungus produces proteins to suppress the plant immune response. Proteins of the Pathogenesis...

Crystal structure of MpPR-1i, a SCP/TAPS protein from Moniliophthora perniciosa , the fungus that causes witches’ broom disease of cacao

Baroni, Renata M. ; Luo, Zhipu ; Darwiche, Rabih ; Hudspeth, Elissa M. ; Schneiter, Roger ; Pereira, Gonçalo A. G. ; Mondego, Jorge M. C. ; Asojo, Oluwatoyin A.

In: Scientific Reports, 2017, vol. 7, no. 1, p. 7818

The pathogenic fungi Moniliophthora perniciosa causes Witches’ Broom Disease (WBD) of cacao. The structure of MpPR-1i, a protein expressed by M. perniciosa when it infects cacao, are presented. This is the first reported de novo structure determined by single-wavelength anomalous dispersion phasing upon soaking with selenourea. Each monomer has flexible loop regions linking the core...

Nailfold capillary abnormalities in erectile dysfunction of systemic sclerosis: a EUSTAR group analysis

Keck, Andrea D. ; Foocharoen, Chingching ; Rosato, Edoardo ; Smith, Vanessa ; Allanore, Yannick ; Distler, Oliver ; Stamenkovic, Bojana ; Pereira Da Silva, José Antonio ; Hadj Khelifa, Sondess ; Denisov, Lev N. ; Hachulla, Eric ; García de la Peña Lefebvre, Paloma ; Sibilia, Jean ; Airò, Paolo ; Caramaschi, Paola ; Müller-Ladner, Ulf ; Wiland, Piotr ; Walker, Ulrich A.

In: Rheumatology, 2014, vol. 53, no. 4, p. 639-643

Muscle-specific function of the centronuclear myopathy and Charcot-Marie-Tooth neuropathy-associated dynamin 2 is required for proper lipid metabolism, mitochondria, muscle fibers, neuromuscular junctions and peripheral nerves

Tinelli, Elisa ; Pereira, Jorge A. ; Suter, Ueli

In: Human Molecular Genetics, 2013, vol. 22, no. 21, p. 4417-4429

The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease

Niemann, Axel ; Huber, Nina ; Wagner, Konstanze M. ; Somandin, Christian ; Horn, Michael ; Lebrun-Julien, Frédéric ; Angst, Brigitte ; Pereira, Jorge A. ; Halfter, Hartmut ; Welzl, Hans ; Feltri, M. Laura ; Wrabetz, Lawrence ; Young, Peter ; Wessig, Carsten ; Toyka, Klaus V. ; Suter, Ueli

In: Brain, 2014, vol. 137, no. 3, p. 668-682

Parenteral lipid emulsions and phagocytic systems

Waitzberg, D. L. ; Lotierzo, P. H. ; Logullo, A. F. ; Torrinhas, R. S. M. ; Pereira, C. C. A. ; Meier, Rémy

In: British Journal of Nutrition, 2002, vol. 87, no. S1, p. S49-S57

Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells

Horn, Michael ; Baumann, Reto ; Pereira, Jorge A. ; Sidiropoulos, Páris N. M. ; Somandin, Christian ; Welzl, Hans ; Stendel, Claudia ; Lühmann, Tessa ; Wessig, Carsten ; Toyka, Klaus V. ; Relvas, João B. ; Senderek, Jan ; Suter, Ueli

In: Brain, 2012, vol. 135, no. 12, p. 3567-3583