In: Journal of Cellular Physiology, 2020, p. jcp.29814
Elevated arginase type II (Arg‐II) associates with higher grade tumors. Its function and underlying molecular mechanisms in melanoma remain elusive. In the present study, we observed a significantly higher frequency of Arg‐II expression in melanoma of patients with metastasis than those without metastasis. Silencing Arg‐II in two human melanoma cell lines slowed down the cell growth,...
- Email: xiu-fen.ming@unifr.ch (X....
- Targeting arginase would thus be a
Yuyan Xiong
novel promising therapeutic approach for cancers with elevated
Xiu‐Fen Ming
http://orcid.org/0000-0002-5848-4496
arginase in plasma and/or in the tumors....
- Ming, X....
|
In: Frontiers in Physiology, 2019, vol. 10, p. -
Hypoxia plays a crucial role in the pathogenesis of cardiovascular diseases. Mitochondrial enzyme arginase type II (Arg-II) is reported to lead to endothelial dysfunction and enhance the expression of endothelial inflammatory adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). In this study, we investigate the role of Arg-II in...
- ORIGINAL RESEARCH
published: 14 August 2019
doi: 10.3389/fphys.2019.01003
Hypoxia Enhances Endothelial
Intercellular Adhesion Molecule 1
Protein Level Through Upregulation
of Arginase Type II and Mitochondrial
Oxidative Stress
Xiujie Liang†, Prakash Arullampalam†, Zhihong Yang and Xiu-Fen Ming*
Laboratory of Cardiovascular and Aging Research, Medicine Section, Department of Endocrinology, Metabolism, and
Cardiovascular System, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland
Edited by:
Vincenzo Lionetti,
Sant’Anna School of Advanced
Studies, Italy
Reviewed by:
Ningjun Li,
Virginia Commonwealth University,
United States
Francesca Forini,
Italian National Research
Council, Italy
*Correspondence:
Xiu-Fen Ming
xiu-fen.ming@unifr.ch
†
These authors have contributed
equally to this work
Specialty section:
This article was submitted to
Vascular Physiology,
a section of the journal
Frontiers in Physiology
Received: 04 March 2019
Accepted: 19 July 2019
Published: 14 August 2019
Citation:
Liang X, Arullampalam P, Yang Z and
Ming X-F (2019) Hypoxia Enhances
Endothelial Intercellular Adhesion
Molecule 1 Protein Level Through
Upregulation of Arginase Type II and
Mitochondrial Oxidative Stress....
- P., Yang, Z., and Ming, X....
- P.,
Ming, X....
|
In: Frontiers in Physiology, 2017, vol. 8, p. -
The mitochondrial arginase type II (Arg-II) has been shown to interact with ribosomal protein S6 kinase 1 (S6K1) and mitochondrial p66Shc and to promote cell senescence, apoptosis and inflammation under pathological conditions. However, the impact of Arg-II on organismal lifespan is not known. In this study, we demonstrate a significant lifespan extension in mice with Arg-II gene deficiency...
- ORIGINAL RESEARCH
published: 08 September 2017
doi: 10.3389/fphys.2017.00682
Arginase-II Deficiency Extends
Lifespan in Mice
Yuyan Xiong 1 , Gautham Yepuri 1 , Jean-Pierre Montani 1, 2 , Xiu-Fen Ming 1, 2* and
Zhihong Yang 1, 2*
1
Division of Physiology, Cardiovascular and Aging Research, Department of Medicine, University of Fribourg, Fribourg,
Switzerland, 2 National Center of Competence in Research “Kidney.CH”, Fribourg, Switzerland
Edited by:
Ovidiu Constantin Baltatu,
Anhembi Morumbi University, Brazil
Reviewed by:
Anita Coral Thomas,
University of Bristol, United Kingdom
Robert Lee-Young,
Monash University, Australia
*Correspondence:
Xiu-Fen Ming
xiu-fen.ming@unifr.ch
Zhihong Yang
zhihong.yang@unifr.ch
Specialty section:
This article was submitted to
Integrative Physiology,
a section of the journal
Frontiers in Physiology
Received: 12 May 2017
Accepted: 25 August 2017
Published: 08 September 2017
Citation:
Xiong Y, Yepuri G, Montani J-P,
Ming X-F and Yang Z (2017)
Arginase-II Deficiency Extends
Lifespan in Mice....
- P., Ming, X....
- P.,
Ming, X....
|
In: Cardiovascular Research, 2011, vol. 89, no. 3, p. 485-486
- Zhihong Yang * and Xiu-Fen Ming
´
Laboratory of Vascular Biology, Department of Medicine, Division of Physiology, Faculty of Science, University of Fribourg, Rue du Musee 5, CH-1700 Fribourg, Switzerland
Online publish-ahead-of-print 21 December 2010
This editorial refers to ‘A CD36-dependent pathway
enhances macrophage and adipose tissue inflammation and
impairs insulin signalling’ by D.J....
- Yang Z, Ming XF....
|
In: Diabetes, 2017, vol. 66, no. 6, p. 1636–1649
Aging is associated with glucose intolerance. Arginase-II (Arg-II), the type-II L-arginine- ureahydrolase, is highly expressed in pancreas. However, its role in regulation of pancreatic β-cell function is not known. Here we show that female (not male) mice deficient in Arg-II (Arg-II−/−) are protected from age-associated glucose intolerance and reveal greater glucose induced-insulin...
- Arginase-II Promotes Tumor Necrosis Factor-a Release
From Pancreatic Acinar Cells Causing b-Cell Apoptosis
in Aging
Yuyan Xiong,1,2 Gautham Yepuri,1 Sevil Necetin,1 Jean-Pierre Montani,1,2 Xiu-Fen Ming,1,2 and
Zhihong Yang1,2
Aging is associated with glucose intolerance....
- Corresponding authors: Xiu-Fen Ming, xiu-fen.ming@unifr.ch, and Zhihong Yang,
zhihong.yang@unifr.ch.
1
https://doc.rero.ch
inflammation (25)....
- Yang Z, Ming XF....
|
In: Frontiers in Physiology, 2016, vol. 7, p. -
Obesity is associated with development and progression of chronic kidney disease (CKD). Recent evidence demonstrates that enhanced levels of the L- arginine:ureahydrolase, including the two isoenzymes arginase-I (Arg-I) and arginase- II (Arg-II) in vascular endothelial cells promote uncoupling of endothelial nitric oxide synthase (eNOS), leading to increased superoxide radical anion and...
- ORIGINAL RESEARCH
published: 22 November 2016
doi: 10.3389/fphys.2016.00560
Genetic Targeting of Arginase-II in
Mouse Prevents Renal Oxidative
Stress and Inflammation in
Diet-Induced Obesity
Ji Huang 1, 2 † , Angana Rajapakse 1 † , Yuyan Xiong 1 , Jean-Pierre Montani 1, 2 ,
François Verrey 2, 3 , Xiu-Fen Ming 1, 2* and Zhihong Yang 1, 2*
1
Cardiovascular and Aging Research, Division of Physiology, Department of Medicine, University of Fribourg, Fribourg,
Switzerland, 2 Swiss National Centre of Competence in Research (NCCR) Kidney Control of Homeostasis “Kidney.CH”,
Zurich, Switzerland, 3 Institute of Physiology, University of Zurich, Zurich, Switzerland
Edited by:
Ovidiu Constantin Baltatu,
Anhembi Morumbi University, Brazil
Reviewed by:
Paul Kenneth Witting,
University of Sydney, Australia
Charles Dudley Mills,
BioMedical Consultants, USA
*Correspondence:
Xiu-Fen Ming
xiu-fen.ming@unifr.ch
Zhihong Yang
zhihong.yang@unifr.ch
†
These authors have contributed
equally to this work....
- P., Yang, Z., and Ming, X....
- P., Ming,
X....
|
In: Frontiers in Inflammation, 2013, vol. 4, p. 149
Oxidative stress and inflammation in the vascular wall are essential mechanisms of atherosclerosis and vascular dysfunctions associated with risk factors such as metabolic diseases, aging, hypertension, etc. Evidence has been provided that activation of the vascular endothelial cells in the presence of the risk factors promotes oxidative stress and vascular inflammatory responses, leading to...
- REVIEW ARTICLE
published: 12 June 2013 doi: 10.3389/fimmu.2013.00149
Arginase: the emerging therapeutic target for vascular oxidative stress and inflammation
Zhihong Yang* and Xiu-Fen Ming*
Vascular Biology, Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
Edited by: Rudolf Lucas, Medical College of Georgia, USA Reviewed by: Rita Tostes, University of Sao Paulo, Brazil Yunchao Su, Georgia Regents University, USA *Correspondence: Zhihong Yang and Xiu-Fen Ming, Vascular Biology, Division of Physiology, Department of Medicine, Faculty of Science, University of Fribourg, Chemin du Musée 5, CH-1700 Fribourg, Switzerland e-mail: zhihong.yang@unifr.ch; xiu-fen.ming@unifr.ch
Oxidative stress and inflammation in the vascular wall are essential mechanisms of atherosclerosis and vascular dysfunctions associated with risk factors such as metabolic diseases, aging, hypertension, etc....
- Yang, Z., and Ming, X....
- P., Ming, X....
|
In: Aging Cell, 2012, p. -
Augmented activities of both arginase and S6K1 are involved in endothelial dysfunction in aging. This study was to investigate whether or not there is a crosstalk between arginase and S6K1 in endothelial inflammation and aging in senescent human umbilical vein endothelial cells and in aging mouse models. We show increased arginase-II (Arg-II) expression/activity in senescent endothelial cells....
- Rajapakse, Jean-Pierre Montani, Xiu-Fen Ming and Zhihong Yang
Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Fribourg, Switzerland
Summary
Augmented activities of both arginase and S6K1 are involved in endothelial dysfunction in aging....
- https://doc.rero.ch
Correspondence Zhihong Yang, MD and Xiu-Fen Ming, Department of Medicine, Division of Phys´e iology, University of Fribourg, Chemin du Muse 5, CH-1700 Fribourg, Switzerland....
- Rajapakse, Jean-Pierre Montani, Xiu-Fen Ming†, Zhihong Yang† Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Switzerland Supporting Information listing Supplementary figure legends Fig....
|
In: Febs Letters, 2010, vol. 58, no. 1, p. 135-140
Rapamycin has been reported to enhance tissue factor (TF) expression. The present study investigated roles of mammalian target of rapamycin (mTOR) and its downstream S6K1 in this process. We showed here that, consistent with rapamycin, knocking-down mTOR enhanced thrombin-induced TF mRNA and protein levels, whereas silencing S6K1 mitigated up-regulation of TF protein but not TF mRNA level. The...
- Opposing and uncoupling effects of mTOR and S6K1 in the regulation of endothelial tissue factor expression
Xiu-Fen Ming *, Angana Gupta Rajapakse, João Miguel Carvas, Jean Ruffieux, Zhihong Yang
Division of Physiology, Department of Medicine, University of Fribourg, Switzerland
https://doc.rero.ch
Rapamycin has been reported to enhance tissue factor (TF) expression....
- E-mail address: xiu-fen.ming@unifr.ch (X....
- Ming)....
|
In: BMC Cardiovascular Disorders, 2009, vol. 9, no. 12, p. -
Background: Pharmacological inhibition of endothelial arginase-II has been shown to improve endothelial nitric oxide synthase (eNOS) function and reduce atherogenesis in animal models. We investigated whether the endothelial arginase II is involved in inflammatory responses in endothelial cells. Methods: Human endothelial cells were isolated from umbilical veins and stimulated with TNFα (10...
- BMC Cardiovascular Disorders
Research article
BioMed Central
Open Access
Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline
Xiu-Fen Ming, Angana Gupta Rajapakse, João Miguel Carvas, Jean Ruffieux and Zhihong Yang*
Address: Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Switzerland Email: Xiu-Fen Ming - xiu-fen.ming@unifr.ch; Angana Gupta Rajapakse - angana.rajapakse@gmail.com; João Miguel Carvas - joaomiguel.carvas@unifr.ch; Jean Ruffieux - jean.ruffieux@unifr.ch; Zhihong Yang* - zhihong.yang@unifr.ch * Corresponding author
Published: 13 March 2009 BMC Cardiovascular Disorders 2009, 9:12 doi:10.1186/1471-2261-9-12
Received: 5 November 2008 Accepted: 13 March 2009
This article is available from: http://www.biomedcentral.com/1471-2261/9/12 © 2009 Ming et al; licensee BioMed Central Ltd....
- Yang Z, Ming XF: Recent advances in understanding endothelial dysfunction in atherosclerosis....
- Yang Z, Ming XF: Endothelial arginase: a new target in atherosclerosis....
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