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Fungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinerea

Kretschmer, Matthias ; Leroch, Michaela ; Mosbach, Andreas ; Walker, Anne-Sophie ; Fillinger, Sabine ; Mernke, Dennis ; Schoonbeek, Henk-jan ; Pradier, Jean-Marc ; Leroux, Pierre ; Waard, Maarten A. De ; Hahn, Matthias

In: PLoS Pathogens, 2009, vol. 5, no. 12, p. e1000696

The grey mould fungus Botrytis cinerea causes losses of commercially important fruits, vegetables and ornamentals worldwide. Fungicide treatments are effective for disease control, but bear the risk of resistance development. The major resistance mechanism in fungi is target protein modification resulting in reduced drug binding. Multiple drug resistance (MDR) caused by increased efflux activity...