Université de Fribourg

Period 2 regulates neural stem/progenitor cell proliferation in the adult hippocampus

Borgs, Laurence ; Beukelaers, Pierre ; Vandenbosch, Renaud ; Nguyen, Laurent ; Moonen, Gustave ; Maquet, Pierre ; Albrecht, Urs ; Belachew, Shibeshih ; Malgrange, Brigitte

In: BMC Neuroscience, 2009, vol. 10, p. 30

Background: Newborn granule neurons are generated from proliferating neural stem/progenitor cells and integrated into mature synaptic networks in the adult dentate gyrus of the hippocampus. Since light/dark variations of the mitotic index and DNA synthesis occur in many tissues, we wanted to unravel the role of the clock-controlled Period2 gene (mPer2) in timing cell cycle kinetics and...