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Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making

Khani, Abbas ; Kermani, Mojtaba ; Hesam, Soghra ; Haghparast, Abbas ; Argandoña, Enrike ; Rainer, Gregor

In: Psychopharmacology, 2015, vol. 232, no. 12, p. 2097-2112

Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making

Khani, Abbas ; Kermani, Mojtaba ; Hesam, Soghra ; Haghparast, Abbas ; Argandoña, Enrike G. ; Rainer, Gregor

In: Psychopharmacology, 2015, vol. 232, no. 12, p. 2097–2112

Despite the evidence for altered decision making in cannabis abusers, the role of the cannabinoid system in decision-making circuits has not been studied. Here, we examined the effects of cannabinoid modulation during cost-benefit decision making in the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC), key brain areas involved in decision making. We trained different groups of...