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Synchronizing nuclear import of ribosomal proteins with ribosome assembly

Kressler, Dieter ; Bange, Gert ; Ogawa, Yutaka ; Stjepanovic, Goran ; Bradatsch, Bettina ; Pratte, Dagmar ; Amlacher, Stefan ; Strauß, Daniela ; Yoneda, Yoshihiro ; Katahira, Jun ; Sinning, Irmgard ; Hurt, Ed

In: Science, 2012, vol. 338, no. 6107, p. 666-671

Ribosomal proteins are synthesized in the cytoplasm, before nuclear import and assembly with ribosomal RNA (rRNA). Little is known about coordination of nucleocytoplasmic transport with ribosome assembly. Here, we identify a transport adaptor, symportin 1 (Syo1), that facilitates synchronized coimport of the two 5S-rRNA binding proteins Rpl5 and Rpl11. In vitro studies revealed that Syo1...