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    Université de Fribourg

    Nanodomain coupling between Ca2+ channels and Ca2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapse

    Bucurenciu, Iancu ; Kulik, Akos ; Schwaller, Beat ; Frotscher, Michael ; Jonas, Peter

    In: Neuron, 2008, vol. 57, no. 4, p. 536-545

    It is generally thought that transmitter release at mammalian central synapses is triggered by Ca²⁺ microdomains, implying loose coupling between presynaptic Ca²⁺ channels and Ca²⁺ sensors of exocytosis. Here we show that Ca²⁺ channel subunit immunoreactivity is highly concentrated in the active zone of GABAergic presynaptic terminals of putative parvalbumin-containing basket cells in...