Université de Fribourg

Dual targeting of a single tRNATrp requires two different tryptophanyl-tRNA synthetases in Trypanosoma brucei

Charrière, Fabien ; Helgadóttir, Sunna ; Horn, Elke K. ; Söll, Dieter ; Schneider, André

In: Proceedings of the National Academy of Sciences of the United States of America, 2006, vol. 103, p. 6847-6852

The mitochondrion of Trypanosoma brucei does not encode any tRNAs. This deficiency is compensated for by the import of a small fraction of nearly all of its cytosolic tRNAs. Most trypanosomal aminoacyl-tRNA synthetases are encoded by single-copy genes, suggesting the use of the same enzyme in the cytosol and mitochondrion. However, the T. brucei genome contains two distinct genes...

Université de Fribourg

Non-canonical eukaryotic glutaminyl- and glutamyl-tRNA synthetases form mitochondrial aminoacyl-tRNA in Trypanosoma brucei

Rinehart, Jesse ; Horn, Elke K. ; Wei, David ; Söll, Dieter ; Schneider, André

In: Journal of Biological Chemistry, 2004, vol. 279, p. 1161-1166

Glutaminyl-tRNA synthetase is thought to be absent from organelles. Instead, Gln-tRNA is formed via the transamidation pathway, the other route to this essential compound in protein biosynthesis. However, it was previously shown that glutaminyl-tRNA synthetase activity is present in Leishmania mitochondria. This work identifies genes encoding glutaminyl- and glutamyl-tRNA synthetase in the...

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2 Horn, Elke K.