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Université de Fribourg

Myocardial infarction stabilization by cell-based expression of controlled Vascular Endothelial Growth Factor levels

Melly, Ludovic ; Cerino, Giulia ; Frobert, Aurélien ; Cook, Stéphane ; Giraud, Marie-Noëlle ; Carrel, Thierry ; Tevaearai Stahel, Hendrik T. ; Eckstein, Friedrich ; Rondelet, Benoît ; Marsano, Anna ; Banfi, Andrea

In: Journal of Cellular and Molecular Medicine, 2018, p. -

Vascular Endothelial Growth Factor (VEGF) can induce normal or aberrant angiogenesis depending on the amount secreted in the microenvironment around each cell. Towards a possible clinical translation, we developed a Fluorescence Activated Cell Sorting (FACS)‐based technique to rapidly purify transduced progenitors that homogeneously express a desired specific VEGF level from heterogeneous...

Université de Fribourg

Anisotropically oriented electrospun matrices with an imprinted periodic micropattern: a new scaffold for engineered muscle constructs

Guex, Anne Géraldine ; Birrer, Dominique Lisa ; Fortunato, Giuseppino ; Tevaearai, Hendrik Tinorua ; Giraud, Marie-Noëlle

In: Biomedical Materials, 2013, vol. 8, no. 2, p. 021001

Engineered muscle constructs provide a promising perspective on the regeneration or substitution of irreversibly damaged skeletal muscle. However, the highly ordered structure of native muscle tissue necessitates special consideration during scaffold development. Multiple approaches to the design of anisotropically structured substrates with grooved micropatterns or parallel-aligned fibres have...

Université de Fribourg

Early reperfusion hemodynamics predict recovery in rat hearts: a potential approach towards evaluating cardiac grafts from non-heart-beating donors

Dornbierer, Monika ; Stadelmann, Mathieu ; Sourdon, Joevin ; Gahl, Brigitta ; Cook, Stéphane ; Carrel, Thierry P. ; Tevaearai, Hendrik T. ; Longnus, Sarah L.

In: PLoS ONE, 2012, vol. 7, no. 8, p. e43642

Aims: Cardiac grafts from non-heartbeating donors (NHBDs) could significantly increase organ availability and reduce waiting-list mortality. Reluctance to exploit hearts from NHBDs arises from obligatory delays in procurement leading to periods of warm ischemia and possible subsequent contractile dysfunction. Means for early prediction of graft suitability prior to transplantation are thus...

Université de Fribourg

Cell therapies for heart function recovery: focus on myocardial tissue engineering and nanotechnologies

Giraud, Marie Noëlle ; Guex, Anne Géraldine ; Tevaearai, Hendrik T.

In: Cardiology Research and Practice, 2012, p. -

Cell therapies have gained increasing interest and developed in several approaches related to the treatment of damaged myocardium. The results of multiple clinical trials have already been reported, almost exclusively involving the direct injection of stem cells. It has, however, been postulated that the efficiency of injected cells could possibly be hindered by the mechanical trauma due to the...