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Formation of drug nanocrystals under nanoconfinement afforded by liposomes

Cipolla, D. ; Wu, H. ; Salentinig, S. ; Boyd, B. ; Rades, T. ; Vanhecke, Dimitri ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Eastman, S. ; Redelmeier, T. ; Gonda, I. ; Chan, H. K.

In: RSC Advances, 2016, vol. 6, no. 8, p. 6223–6233

Nanocrystals of drug substances have important therapeutic applications, but their preparation is often difficult due to size control in bottom up approaches, or energetic milling and surface activation in top down processing. In this study, confinement within liposome nanocompartments is demonstrated to enable drug crystallization with a high aspect ratio but limited growth resulting in...