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A dual epimorphic and compensatory mode of heart regeneration in zebrafish

Sallin, Pauline ; Preux Charles, Anne-Sophie de ; Duruz, Vincent ; Pfefferli, Catherine ; Jaźwińska, Anna

In: Developmental Biology, 2015, vol. 399, no. 1, p. 27–40

Zebrafish heart regeneration relies on the capacity of cardiomyocytes to proliferate upon injury. To understand the principles of this process after cryoinjury-induced myocardial infarction, we established a spatio-temporal map of mitotic cardiomyocytes and their differentiation dynamics. Immunodetection of phosphohistone H3 and embryonic ventricular heavy chain myosin highlighted two distinct...