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Structural basis for different substrate profiles of two closely related class D β-lactamases and their inhibition by halogens

Stojanoski, Vlatko ; Chow, Dar-Chone ; Fryszczyn, Bartlomiej ; Hu, Liya ; Nordmann, Patrice ; Poirel, Laurent ; Sankaran, Banumathi ; Prasad, B. V. Venkataram ; Palzkill, Timothy

In: Biochemistry, 2015, vol. 54, no. 21, p. 3370–3380

OXA-163 and OXA-48 are closely related class D β-lactamases that exhibit different substrate profiles. OXA-163 hydrolyzes oxyimino-cephalosporins, particularly ceftazidime, while OXA-48 prefers carbapenem substrates. OXA-163 differs from OXA-48 by one substitution (S212D) in the active-site β5 strand and a four-amino acid deletion (214-RIEP-217) in the loop connecting the β5 and β6 strands....