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    Université de Fribourg

    Yeast endosulfines control entry into quiescence and chronological life span by inhibiting protein phosphatase 2A

    Bontron, Séverine ; Jaquenoud, Malika ; Vaga, Stefania ; Talarek, Nicolas ; Bodenmiller, Bernd ; Aebersold, Ruedi ; De Virgilio, Claudio

    In: Cell Reports, 2012, vol. 3, no. 1, p. 16–22

    The TORC1 and PKA protein kinases are central elements of signaling networks that regulate eukaryotic cell proliferation in response to growth factors and/or nutrients. In yeast, attenuation of signaling by these kinases following nitrogen and/or carbon limitation activates the protein kinase Rim15, which orchestrates the initiation of a reversible cellular quiescence program to ensure normal...