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Over-expression of parvalbumin in transgenic mice rescues motoneurons from injury-induced cell death

Dekkers, J. ; Bayley, P. ; Dick, J. R. T. ; Schwaller, Beat ; Berchtold, M. W. ; Greensmith, L.

In: Neuroscience, 2004, vol. 123(2), p. 459-466

Following nerve injury in neonatal rats, a large proportion of motoneurons die, possibly as a consequence of an increase in vulnerability to the excitotoxic effects of glutamate. Calcium-dependent glutamate excitotoxicity is thought to play a significant role not only in injury-induced motoneuron death, but also in motoneuron degeneration in diseases such as amyotrophic lateral sclerosis (ALS)....