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DMSO-induced denaturation of hen egg white lysozyme

Voets, Ilja K. ; Cruz, Willemberg A. ; Moitzi, Christian ; Lindner, Peter ; Arêas, Elizabeth P. G. ; Schurtenberger, Peter

In: The Journal of Physical Chemistry B, 2010, vol. 114, p. 11875–11883

We report on the size, shape, structure, and interactions of lysozyme in the ternary system lysozyme/DMSO/water at low protein concentrations. Three structural regimes have been identified, which we term the “folded” (0 DMSO DMSO DMSO < 1.0) regime. Lysozyme resides in a...