In: The Journal of Clinical Endocrinology & Metabolism, 2016, vol. 101, no. 9, p. 3409-3418
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In: The Journal of Clinical Endocrinology & Metabolism, 2016, vol. 101, no. 12, p. 4789-4798
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In: Molecular and Cellular Endocrinology, 2013, vol. 371, no. 1-2, p. 124–132
Following development of the fetal bipotential gonad into a testis, male genital differentiation requires testicular androgens. Fetal Leydig cells produce testosterone that is converted to dihydrotestosterone in genital skin, resulting in labio-scrotal fusion. An alternative ‘backdoor’ pathway of dihydrotestosterone synthesis that bypasses testosterone has been described in marsupials, but...
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