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Angiogenic signalling pathways altered in gliomas: selection mechanisms for more aggressive neoplastic subpopulations with invasive phenotype

Bulnes, Susana ; Bengoetxea, Harkaitz ; Ortuzar, Naiara ; Argandoña, Enrike G. ; Garcia-Blanco, Álvaro ; Rico-Barrio, Irantzu ; Lafuente, José V.

In: Journal of Signal Transduction, 2012, p. 597915

The angiogenesis process is a key event for glioma survival, malignancy and growth. The start of angiogenesis is mediated by a cascade of intratumoural events: alteration of the microvasculature network; a hypoxic microenvironment; adaptation of neoplastic cells and synthesis of pro-angiogenic factors. Due to a chaotic blood flow, a consequence of an aberrant microvasculature, tissue hypoxia...