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Saturable metabolism of continuous high-dose ifosfamide with Mesna and GM-CSF: A pharmacokinetic study in advanced sarcoma patients

Cerny, T. ; Leyvraz, S. ; von Briel, T. ; Küpfer, A. ; Schaad, R. ; Hsu Schmitz, S.-F ; Honegger, P. ; Sessa, C. ; Brunner, J. ; Boddy, A. V.

In: Annals of Oncology, 1999, vol. 10, no. 9, p. 1087-1094

Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens

Wyen, Christoph ; Hendra, Heidy ; Siccardi, Marco ; Platten, Martin ; Jaeger, Hans ; Harrer, Thomas ; Esser, Stefan ; Bogner, Johannes R. ; Brockmeyer, Norbert H. ; Bieniek, Bernhard ; Rockstroh, Juergen ; Hoffmann, Christian ; Stoehr, Albrecht ; Michalik, Claudia ; Dlugay, Verena ; Jetter, Alexander ; Knechten, Heribert ; Klinker, Hartwig ; Skaletz-Rorowski, Adriane ; Fätkenheuer, Gerd ; Egan, Deirdre ; Back, David J. ; Owen, Andrew ; Dupke, Stephan ; Carganico, Andreas ; Baumgarten, Axel ; Koeppe, Siegfried ; Kreckel, Peter ; Lauenroth-Mai, Elke ; Schlote, Frank ; Schuler, Christoph ; Freiwald, Matthias ; Rausch, Michael ; Gölz, Jörg ; Moll, Arend ; Zeitz, Martin ; Brockmeyer, Norbert ; Hower, Martin ; Reuter, Stefan ; Harrer, Thomas ; Esser, Stefan ; Staszewski, Schlomo ; Plettenberg, Andreas ; Fenske, Stefan ; Buhk, Thomas ; Stellbrink, Hans-Jürgen ; Schmidt, Reinhold ; Kuhlmann, Birger ; Mosthaf, Franz ; Rieke, Ansgar ; Scholten, Stefan ; Jaeger, Hans ; Jaegel-Guedes, Eva ; Volkert, Ramona ; Becker, Werner ; Hartl, Helmut ; Mutz, Antonius ; Ulmer, Albrecht ; Frietsch, Bernhard ; Müller, Markus

In: Journal of Antimicrobial Chemotherapy, 2011, vol. 66, no. 9, p. 2092-2098

Relative Contributions of Genes, Environment, and Interactions to Blood Lipid Concentrations in a General Adult Population

Costanza, Michael C. ; Cayanis, Eftihia ; Ross, Barbara M. ; Flaherty, Maria Sol ; Alvin, Gabriela B. ; Das, Kamna ; Morabia, Alfredo

In: American Journal of Epidemiology, 2005, vol. 161, no. 8, p. 714-724

Comparison of fresh and ensiled white and red clover added to ryegrass on energy and protein utilization of lactating cows

van Dorland, H. A. ; Wettstein, H.-R ; Leuenberger, H. ; Kreuzer, M.

In: Animal Science, 2006, vol. 82, no. 5, p. 691-700

Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death

Ronellenfitsch, Michael W. ; Brucker, Daniel P. ; Burger, Michael C. ; Wolking, Stefan ; Tritschler, Felix ; Rieger, Johannes ; Wick, Wolfgang ; Weller, Michael ; Steinbach, Joachim P.

In: Brain, 2009, vol. 132, no. 6, p. 1509-1522

Parameters Affecting the Early Seedling Development of Four Neotropical Trees under Oxygen Deprivation Stress

KOLB, ROSANA MARTA ; RAWYLER, ANDRÉ ; BRAENDLE, ROLAND

In: Annals of Botany, 2002, vol. 89, no. 5, p. 551-558

Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany

Müller, M. J. ; Baracos, V. ; Bosy-Westphal, A. ; Dulloo, Abdul G. ; Eckel, J. ; Fearon, K. C. H. ; Hall, K. D. ; Pietrobelli, A. ; Sørensen, T. I. A. ; Speakman, J. ; Trayhurn, P. ; Visser, M. ; Heymsfield, S. B.

In: Obesity Reviews, 2014, vol. 15, no. 8, p. 640–656

The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia. The concept of ‘functional body composition’ integrates body components into regulatory systems relating the mass of organs and tissues to corresponding in vivo functions and metabolic processes. This concept adds to an understanding of organ/tissue mass and...

Cytosolic pH is a second messenger for glucose and regulates the PKA pathway through V-ATPase

Dechant, Reinhard ; Binda, Matteo ; Lee, Sung Sik ; Pelet, Serge ; Winderickx, Joris ; Peter, Matthias

In: Embo Journal, 2010, vol. 29, no. 15, p. 2515-2526

Glucose is the preferred carbon source for most cell types and a major determinant of cell growth. In yeast and certain mammalian cells, glucose activates the cAMP-dependent protein kinase A (PKA), but the mechanisms of PKA activation remain unknown. Here, we identify cytosolic pH as a second messenger for glucose that mediates activation of the PKA pathway in yeast. We find that cytosolic pH is...

Orchestration of gene expression and physiology by the circadian clock

Albrecht, Urs

In: Journal of Physiology-Paris, 2006, vol. 100, no. 5-6, p. 243-251

In mammals, the master circadian clock that drives many biochemical, physiological and behavioral rhythms is located in the suprachiasmatic nuclei (SCN) of the hypothalamus. Generation and maintenance of circadian rhythms rely on complex interlaced feedback loops based on transcriptional and posttranscriptional events involving clock genes and kinases. This clock serves the purpose to organize an...

Life time—circadian clocks, mitochondria and metabolism

Langmesser, Sonja ; Albrecht, Urs

In: Chronobiology International, 2006, vol. 23, no. 1-2, p. 51–157

A functional circadian clock has long been considered a selective advantage. Accumulating evidence shows that the clock coordinates a variety of physiological processes in order to schedule them to the optimal time of day and thus to synchronize metabolism to changes in external conditions. In mitochondria, both metabolic and cellular defense mechanisms are carefully regulated. Abnormal clock...