Università della Svizzera italiana

PECAM-1 stabilizes blood-brain barrier integrity and favors paracellular T-Cell diapedesis across the blood-brain barrier during neuroinflammation

Wimmer, Isabella ; Tietz, Silvia ; Nishihara, Hideaki ; Deutsch, Urban ; Sallusto, Federica ; Gosselet, Fabien ; Lyck, Ruth ; Muller, William A. ; Lassmann, Hans ; Engelhardt, Britta

In: Frontiers in immunology, 2019, vol. 10, p. 711

Breakdown of the blood-brain barrier (BBB) and increased immune cell trafficking into the central nervous system (CNS) are hallmarks of the pathogenesis of multiple sclerosis (MS). Platelet endothelial cell adhesion molecule-1 (PECAM-1; CD31) is expressed on cells of the vascular compartment and regulates vascular integrity and immune cell trafficking. Involvement of PECAM-1 in MS pathogenesis...

Université de Fribourg

Cellular shuttles: monocytes/macrophages exhibit transendothelial transport of nanoparticles under physiological flow

Moore, Thomas L. ; Hauser, Daniel ; Gruber, Thomas ; Rothen-Rutishauser, Barbara ; Lattuada, Marco ; Petri-Fink, Alke ; Lyck, Ruth

In: ACS Applied Materials & Interfaces, 2017, vol. 9, no. 22, p. 18501–18511

A major hurdle in the development of biomedical nanoparticles (NP) is understanding how they interact with complex biological systems and navigate biological barriers to arrive at pathological targets. It is becoming increasingly evident that merely controlling particle physicochemical properties may not be sufficient to mediate particle biodistribution in dynamic environments. Thus,...