Università della Svizzera italiana

Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells

Ronchi, Francesca ; Basso, Camilla ; Preite, Silvia ; Reboldi, Andrea ; Baumjohann, Dirk ; Perlini, Luana ; Lanzavecchia, Antonio ; Sallusto, Federica

In: Nature communications, 2016, vol. 7, p. 11541

CD4+ Th17 are heterogeneous in terms of cytokine production and capacity to initiate autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE). Here we demonstrate that experimental priming of encephalitogenic Th cells expressing RORγt and T-bet and producing IL-17A, IFN-γ and GM-CSF but not IL-10 (Th1/Th17), is dependent on the presence of pertussis toxin (PTX) at the...