Université de Fribourg

Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles

Eisenhardt, Anja E. ; Sprenger, Adrian ; Röring, Michael ; Herr, Ricarda ; Weinberg, Florian ; Köhler, Martin ; Braun, Sandra ; Orth, Joachim ; Diedrich, Britta ; Lanner, Ulrike ; Tscherwinski, Natalja ; Schuster, Simon ; Dumaz, Nicolas ; Schmidt, Enrico ; Baumeister, Ralf ; Schlosser, Andreas ; Dengjel, Jörn ; Brummer, Tilman

In: Oncotarget, 2016, vol. 7, no. 18, p. 26628–26652

B-Raf represents a critical physiological regulator of the Ras/RAF/MEK/ERK-pathway and a pharmacological target of growing clinical relevance, in particular in oncology. To understand how B-Raf itself is regulated, we combined mass spectrometry with genetic approaches to map its interactome in MCF-10A cells as well as in B-Raf deficient murine embryonic fibroblasts (MEFs) and B-Raf/Raf-1...

Consortium of Swiss Academic Libraries

Cell cycle regulation by the B-Myb transcription factor

Joaquin, M. ; Watson, R.

In: Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 11, p. 2389-2401

Université de Fribourg

Epigenetic and posttranslational modifications in light signal transduction and the circadian clock in Neurospora crassa

Proietto, Marco ; Bianchi, Michele Maria ; Ballario, Paola ; Brenna, Andrea

In: International Journal of Molecular Sciences, 2015, vol. 16, no. 7, p. 15347–15383

Blue light, a key abiotic signal, regulates a wide variety of physiological processes in many organisms. One of these phenomena is the circadian rhythm presents in organisms sensitive to the phase-setting effects of blue light and under control of the daily alternation of light and dark. Circadian clocks consist of autoregulatory alternating negative and positive feedback loops intimately...

Consortium of Swiss Academic Libraries

"Jnking” atherosclerosis

Sumara, G. ; Belwal, M. ; Ricci, R.

In: Cellular and Molecular Life Sciences CMLS, 2005, vol. 62, no. 21, p. 2487-2494