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Université de Fribourg

Simple assessment of height and length of flight in complex gymnastic skills: validity and reliability of a two-dimensional video analysis method

Schärer, Christoph ; Siebenthal, Luca von ; Lomax, Ishbel ; Gross, Micah ; Taube, Wolfgang ; Hübner, Klaus

In: Applied Sciences, 2019, vol. 9, no. 19, p. 3975

In artistic gymnastics, the possibility of using 2D video analysis to measure the peak height (hpeak) and length of flight (L) during routine training in order to monitor the execution and development of difficult elements is intriguing. However, the validity and reliability of such measurements remain unclear. Therefore, in this study, the hpeak and L of 38 vaults, performed by top-level...

Université de Fribourg

Stimulus reward value interacts with training-induced plasticity in inhibitory control

Pretto, Michael De ; Hartmann, Lea ; Garcia-Burgos, David ; Sallard, Etienne ; Spierer, Lucas

In: Neuroscience, 2019, vol. 421, p. 82–94

Training inhibitory control, the ability to suppress motor or cognitive processes, not only enhances inhibition processes, but also reduces the perceived value and behaviors toward the stimuli associated with the inhibition goals during the practice. While these findings suggest that inhibitory control training interacts with the aversive and reward systems, the underlying spatio-temporal...

Université de Fribourg

Neurons in the Nucleus papilio contribute to the control of eye movements during REM sleep

Gutierrez Herrera, C. ; Girard, Franck ; Bilella, Alessandro ; Gent, T. C. ; Roccaro-Waldmeyer, Diana M. ; Adamantidis, A. ; Celio, Marco R.

In: Nature Communications, 2019, vol. 10, no. 1, p. 1–11

Rapid eye movements (REM) are characteristic of the eponymous phase of sleep, yet the underlying motor commands remain an enigma. Here, we identified a cluster of Calbindin-D28K-expressing neurons in the Nucleus papilio (NPCalb), located in the dorsal paragigantocellular nucleus, which are active during REM sleep and project to the three contralateral eye-muscle nuclei. The firing of...

Université de Fribourg

No evidence that frontal optical flow affects perceived locomotor speed and locomotor biomechanics when running on a treadmill

Caramenti, Martina ; Lafortuna, Claudio L. ; Mugellini, Elena ; Khaled, Omar Abou ; Bresciani, Jean-Pierre ; Dubois, Amandine

In: Applied Sciences, 2019, vol. 9, no. 21, p. 4589

We investigated how the presentation and the manipulation of an optical flow while running on a treadmill affect perceived locomotor speed (Experiment 1) and gait parameters (Experiment 2). In Experiment 1, 12 healthy participants were instructed to run at an imposed speed and to focus on their sensorimotor sensations to be able to reproduce this running speed later. After a pause, they had...

Université de Fribourg

A biologically-inspired model to predict perceived visual speed as a function of the stimulated portion of the visual field

Solari, Fabio ; Caramenti, Martina ; Chessa, Manuela ; Pretto, Paolo ; Bülthoff, Heinrich H. ; Bresciani, Jean-Pierre

In: Frontiers in Neural Circuits, 2019, vol. 13, p. -

Spatial orientation relies on a representation of the position and orientation of the body relative to the surrounding environment. When navigating in the environment, this representation must be constantly updated taking into account the direction, speed, and amplitude of body motion. Visual information plays an important role in this updating process, notably via optical flow. Here, we...

Université de Fribourg

Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects

Kiss, Tamas ; Giles, Cory B. ; Tarantini, Stefano ; Yabluchanskiy, Andriy ; Balasubramanian, Priya ; Gautam, Tripti ; Csipo, Tamas ; Nyúl-Tóth, Ádám ; Lipecz, Agnes ; Szabo, Csaba ; Farkas, Eszter ; Wren, Jonathan D. ; Csiszar, Anna ; Ungvari, Zoltan

In: Published version; http://dx.doi.org/10.1007/s11357-019-00095-x, 2019, p. -

Understanding molecular mechanisms involved in vascular aging is essential to develop novel interventional strategies for treatment and prevention of age-related vascular pathologies. Recent studies provide critical evidence that vascular aging is characterized by NAD+ depletion. Importantly, in aged mice, restoration of cellular NAD+ levels by treatment with the NAD+ booster nicotinamide...

Université de Fribourg

Nine hole peg test and transcranial magnetic stimulation: useful to evaluate dexterity of the hand and disease progression in amyotrophic lateral sclerosis

Czell, David ; Neuwirth, Christoph ; Weber, Markus ; Sartoretti-Schefer, Sabine ; Gutzeit, Andreas ; Reischauer, Carolin

In: Neurology Research International, 2019, vol. 2019, p. 1–5

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with involvement of the upper and lower motor neurons. Since the loss of fine motor skills is one of the earliest signs of ALS, the hypothesis was tested if the nine hole PEG test (NHPT) and transcranial magnet stimulation (TMS) with resting-motor threshold (RMT) could be useful in monitoring disease progression. Methods. We...

Université de Fribourg

Interpretation of clinical data and hypothesis testing with the aid of self-collected data from physiology laboratory courses: a teaching approach for medical students

Grasser, Erik Konrad ; Montani, Jean-Pierre

In: Advances in Physiology Education, 2019, vol. 43, no. 4, p. 557–560

More than 50 million scientific articles were published between 1665 and 2009 (4), with millions more expected every year (6). This incomprehensible number accounts for scientific articles alone and does not encompass various “pseudo-scientific” information and articles that are spread, without any peer review process, by social media and blogs, thereby generating a potential source of...

Université de Fribourg

Olfactory dysfunction in the pathophysiological continuum of dementia

Bathini, Praveen ; Brai, Emanuele ; Alberi Auber, Lavinia

In: Ageing Research Reviews, 2019, vol. 55, p. 100956

Sensory capacities like smell, taste, hearing, vision decline with aging, but increasing evidence show that sensory dysfunctions are one of the early signs diagnosing the conversion from physiological to pathological brain state. Smell loss represents the best characterized sense in clinical practice and is considered as one of the first preclinical signs of Alzheimer’s and Parkinson’s...

Université de Fribourg

A new alligatoroid from the Eocene of Vietnam highlights an extinct Asian clade independent from extant Alligator sinensis

Massonne, Tobias ; Vasilyan, Davit ; Rabi, Márton ; Böhme, Madelaine

In: PeerJ, 2019, vol. 7, p. e7562

During systematic paleontological surveys in the Na Duong Basin in North Vietnam between 2009 and 2012, well-preserved fossilized cranial and postcranial remains belonging to at least 29 individuals of a middle to late Eocene (late Bartonian to Priabonian age (39–35 Ma)) alligatoroid were collected. Comparative anatomical study of the material warrants the diagnosis of a new taxon,...