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Université de Fribourg

Contrast-induced nephropathy in invasive cardiology: incidence, pathophysiology, diagnosis, prevention and prognosis

Perrin, Tilman ; Descombes, Eric ; Cook, Stéphane

In: Swiss Medical Weekly, 2012, vol. 142, p. w13608

Contrast-induced nephropathy (CIN) is an acute renal injury due to the renal toxicity of iodinated contrast media. It is classically defined as a relative (≥25%) or absolute (≥0.5 mg/dl; 44 μmol/l) increase in serum creatinine from baseline value. CIN accounts for 10 to 15% of hospital-acquired acute renal failure and may rarely lead to irreversible renal function loss. Following...

Université de Fribourg

Balloon angioplasty using the "grip" scoring balloon for treatment of coronary in-stent restenosis - immediate and 12-month clinical outcomes

Puricel, Serban ; Schoepke, Linus ; Togni, Mario ; Oberhänsli, Markus ; Moschovitis, Aris ; Meier, Bernhard ; Windecker, Stephan ; Cook, Stéphane

In: Cardiovascular Medicine, 2012, vol. 15, no. 12, p. 354–361

Objectives: We sought to determine the efficacy and safety of a scoring balloon for the treatment of in-stent restenosis (ISR). Background: The optimal therapy for ISR is not yet properly established and subject to many discussions. The GRIP™ Balloon (Acrostak, Switzerland) might be of interest for the treatment of certain types of ISR. Methods: Between 2003 and 2009, 157 patients who were...

Université de Fribourg

Early reperfusion hemodynamics predict recovery in rat hearts: a potential approach towards evaluating cardiac grafts from non-heart-beating donors

Dornbierer, Monika ; Stadelmann, Mathieu ; Sourdon, Joevin ; Gahl, Brigitta ; Cook, Stéphane ; Carrel, Thierry P. ; Tevaearai, Hendrik T. ; Longnus, Sarah L.

In: PLoS ONE, 2012, vol. 7, no. 8, p. e43642

Aims: Cardiac grafts from non-heartbeating donors (NHBDs) could significantly increase organ availability and reduce waiting-list mortality. Reluctance to exploit hearts from NHBDs arises from obligatory delays in procurement leading to periods of warm ischemia and possible subsequent contractile dysfunction. Means for early prediction of graft suitability prior to transplantation are thus...

Université de Fribourg

Circadian variations of ischemic burden among patients with myocardial infarction undergoing primary percutaneous coronary intervention

Fournier, Stephane ; Eeckhout, Eric ; Mangiacapra, Fabio ; Trana, Catalina ; Lauriers, Nathalie ; Beggah, Ahmed T. ; Monney, Pierre ; Cook, Stéphane ; Bardy, Daniel ; Vogt, Pierre ; Muller, Olivier

In: American Heart Journal, 2012, vol. 163, no. 2, p. 208–213

Background: Several parameters of cardiovascular physiology and pathophysiology exhibit circadian rhythms. Recently, a relation between infarct size and the time of day at which it occurs has been suggested in experimental models of myocardial infarction. The aim of this study is to investigate whether circadian rhythms could cause differences in ischemic burden in patients with ST-elevation...

Université de Fribourg

Percutaneous ventricular assist devices: new deus ex machina?

Arroyo, Diego ; Cook, Stéphane

In: Minimally Invasive Surgery, 2011, p. -

The development of ventricular assist devices has broadened the means with which one can treat acute heart failure. Percutaneous ventricular assist devices (pVAD) have risen from recent technological advances. They are smaller, easier, and faster to implant, all important qualities in the setting of acute heart failure. The present paper briefly describes the functioning and assets of the most...