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Université de Fribourg

Cardiovascular and metabolic responses to the ingestion of caffeinated herbal tea: drink it hot or cold?

Maufrais, Claire ; Sarafian, Delphine ; Dulloo, Abdul ; Montani, Jean-Pierre

In: Frontiers in Physiology, 2018, vol. 9, p. -

Tea is usually consumed at two temperatures (as hot tea or as iced tea). However, the importance of drink temperature on the cardiovascular system and on metabolism has not been thoroughly investigated. The purpose of this study was to compare the cardiovascular, metabolic and cutaneous responses to the ingestion of caffeinated herbal tea (Yerba Mate) at cold or hot temperature in healthy...

Université de Fribourg

Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis

Yu, Yi ; Xiong, Yuyan ; Montani, Jean-Pierre ; Yang, Zhihong ; Ming, Xiu-Fen

In: Cell Death & Disease, 2018, vol. 9, no. 3, p. 313

Type-II L-arginine:ureahydrolase, arginase-II (Arg-II), is shown to activate mechanistic target of rapamycin complex 1 (mTORC1) pathway and contributes to cell senescence and apoptosis. In an attempt to elucidate the underlying mechanism, we identified myosin-1b (Myo1b) as a mediator. Overexpression of Arg-II induces re-distribution of lysosome and mTOR but not of tuberous sclerosis complex...

Université de Fribourg

Impaired social cognition in schizophrenia during the Ultimatum Game: An EEG study

Horat, Sibylle K. ; Favre, Grégoire ; Prévot, Anne ; Ventura, Joseph ; Herrmann, François R. ; Gothuey, Isabelle ; Merlo, Marco C.G. ; Missonnier, Pascal

In: Schizophrenia Research, 2018, vol. 192, p. 308–316

Schizophrenia has a core feature of cognitive dysfunctions. Since these deficits are predictive for patients' functional outcome, understanding their origin is of great importance to improve their daily lives. A specific component of the deficit involves social decision-making, which can be studied using the Ultimatum Game (UG). In this task, a “proposer” proposes a share of money to a...

Université de Fribourg

Are animals a source of Stenotrophomonas maltophilia in human infections? Contributions of a nationwide molecular study

Jayol, Aurélie ; Corlouer, Camille ; Haenni, Marisa ; Darty, Mélanie ; Maillard, Karine ; Desroches, Marine ; Lamy, Brigitte ; Jumas-Bilak, Estelle ; Madec, Jean-Yves ; Decousser, Jean-Winoc

In: European Journal of Clinical Microbiology & Infectious Diseases, 2018, p. 1–7

Stenotrophomonas maltophilia (Sm) is an archetypal environmental opportunistic bacterium responsible for health care-associated infections. The role of animals in human Sm infections is unknown. This study aims to reveal the genetic and phylogenetic relationships between pathogenic strains of Sm, both animal and human, and identify a putative role for animals as a reservoir in human...

Université de Fribourg

Myocardial infarction stabilization by cell-based expression of controlled Vascular Endothelial Growth Factor levels

Melly, Ludovic ; Cerino, Giulia ; Frobert, Aurélien ; Cook, Stéphane ; Giraud, Marie-Noëlle ; Carrel, Thierry ; Tevaearai Stahel, Hendrik T. ; Eckstein, Friedrich ; Rondelet, Benoît ; Marsano, Anna ; Banfi, Andrea

In: Journal of Cellular and Molecular Medicine, 2018, p. -

Vascular Endothelial Growth Factor (VEGF) can induce normal or aberrant angiogenesis depending on the amount secreted in the microenvironment around each cell. Towards a possible clinical translation, we developed a Fluorescence Activated Cell Sorting (FACS)‐based technique to rapidly purify transduced progenitors that homogeneously express a desired specific VEGF level from heterogeneous...

Université de Fribourg

Silver-nanoparticles increase bactericidal activity and radical oxygen responses against bacterial pathogens in human osteoclasts

Aurore, Valerie ; Caldana, Fabienne ; Blanchard, Marianne ; Kharoubi Hess, Solange ; Lannes, Nils ; Mantel, Pierre-Yves ; Filgueira, Luis ; Walch, Michael

In: Nanomedicine: Nanotechnology, Biology and Medicine, 2018, vol. 14, no. 2, p. 601–607

Bone infections are difficult to treat and can lead to severe tissue destruction. Acute bone infections are usually caused by Staphylococcus aureus. Osteoclasts, which belong to the monocyte/macrophage lineage, are the key cells in bone infections. They are not well equipped for killing bacteria and may serve as a reservoir for bacterial pathogens. Silver has been known for centuries for its...

Université de Fribourg

The posterior ridge of the greater tuberosity of the humerus: a suitable landmark for the posterior approach to the shoulder joint?

Grob, Karl ; Monahan, Rebecca Helen ; Manestar, Mirjana ; Filgueira, Luis ; Zdravkovic, Vilijam

In: Journal of Shoulder and Elbow Surgery, 2018, vol. 27, no. 4, p. 635–640

The purpose of this study was to evaluate the posterior ridge of the greater tuberosity, a palpable prominence during surgery, as a landmark for the posterior approach to the glenohumeral joint.Methods: Twenty-five human cadaveric shoulders were dissected. In 5 cases, a full-thickness rotator cuff tear was present. The posterior surgical anatomy was defined, and the distance from the ridge to...

Université de Fribourg

Validation of an ambient system for the measurement of gait parameters

Dubois, Amandine ; Bresciani, Jean-Pierre

In: Journal of Biomechanics, 2018, vol. 69, p. 175–180

Fall risk in elderly people is usually assessed using clinical tests. These tests consist in a subjective evaluation of gait performed by healthcare professionals, most of the time shortly after the first fall occurrence. We propose to complement this one-time, subjective evaluation, by a more quantitative analysis of the gait pattern using a Microsoft Kinect. To evaluate the potential of the...

Université de Fribourg

Decision-making in multiple sclerosis patients: a systematic review

Neuhaus, Mireille ; Calabrese, Pasquale ; Annoni, Jean-Marie

In: Multiple Sclerosis International, 2018, p. -

Background. Multiple sclerosis (MS) is frequently associated with cognitive and behavioural deficits. A growing number of studies suggest an impact of MS on decision-making abilities. The aim of this systematic review was to assess if (1) performance of MS patients in decision-making tasks was consistently different from controls and (2) whether this modification was associated with cognitive...

Université de Fribourg

Behavioral and electrophysiological signatures of word translation processes

Jost, Lea B. ; Radman, Narges ; A.Buetler, Karin ; Annoni, Jean-Marie

In: Neuropsychologia, 2018, vol. 109, p. 245–254

Translation is a demanding process during which a message is analyzed, translated and communicated from one language to another. Despite numerous studies on translation mechanisms, the electrophysiological processes underlying translation with overt production remain largely unexplored. Here, we investigated how behavioral response patterns and spatial-temporal brain dynamics differ in a...