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Université de Fribourg

The dipeptidylpeptidase-IV inhibitors sitagliptin, vildagliptin and saxagliptin do not impair innate and adaptive immune responses

Anz, David ; Kruger, S. ; Haubner, S. ; Rapp, Moritz ; Bourquin, Carole ; Endres, Stefan

In: Diabetes, Obesity and Metabolism, 2014, vol. 16, no. 6, p. 569–572

Inhibitors of dipeptidylpeptidase IV (DPP-IV) represent a novel class of frequently used anti-diabetic drugs. In addition to its function in metabolic regulation, DPP-IV also plays a role in the immune system. Whether the DPP-IV inhibitors sitagliptin, vildagliptin or saxagliptin impair immune responses is, however, currently unknown. Here, we investigated the effect of these agents on both...