Consortium of Swiss Academic Libraries

How astrocytes feed hungry neurons

Pellerin, Luc

In: Molecular Neurobiology, 2005, vol. 32, no. 1, p. 59-72

Université de Fribourg

The hexosamine biosynthesis inhibitor azaserine prevents endothelial inflammation and dysfunction under hyperglycemic condition through antioxidant effects

Rajapakse, Angana Gupta ; Ming, Xiu-Fen ; Carvas, João Miguel ; Yang, Zhihong

In: American Journal of Physiology - Heart and Circulatory Physiology, 2009, vol. 296, p. H815-H822

Hexosamine biosynthetic pathway (HBP) accounts for some cardiovascular adverse effects of hyperglycemia. We investigated whether the HBP inhibitor azaserine protects against hyperglycemia-induced endothelial damage dependently of HBP. Human endothelial cells isolated from umbilical veins were exposed either to a high (30.5 mmol/l) or low concentration of glucose (5.5 mmol/l) for 4 days, followed...