Université de Fribourg

Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition

Gebhard, C. ; Holy, E. W. ; Camici, Giovanni G. ; Akhmedov, Alexander ; Stämpfli, S. F. ; Stähli, B. E. ; Rickenbach, B. von ; Breitenstein, A. ; Greutert, Helen ; Yang, Zhihong ; Lüscher, Thomas F. ; Tanner, Felix C.

In: Thrombosis and Haemostasis, 2012, vol. 107, no. 5, p. 803-1007

Tissue factor (TF) is the key activator of coagulation and is involved in acute coronary syndromes. Caffeine is often reported to increase cardiovascular risk; however, its effect on cardiovascular morbidity and mortality is controversial. Hence, this study was designed to investigate the impact of caffeine on endothelial TF expression in vitro . Caffeine concentration-dependently enhanced TF...

Université de Fribourg

Dimethyl sulfoxide inhibits tissue factor expression, thrombus formation, and vascular smooth muscle cell activation: a potential treatment strategy for drug-eluting stents

Camici, Giovanni G. ; Steffel, Jan ; Akhmedov, Alexander ; Schafer, Nicola ; Baldinger, Jeannette ; Schulz, Urs ; Shojaati, Kushiar ; Matter, Christian M. ; Yang, Zhihong ; Lüscher, Thomas F. ; Tanner, Felix C.

In: Circulation, 2006, vol. 114, no. 14, p. 1512-1521

Background— Subacute stent thrombosis is a major clinical concern, and the search for new molecules to cover stents remains important. Dimethyl sulfoxide (DMSO) is used for preservation of hematopoietic progenitor cells and is infused into patients undergoing bone marrow transplantation. Despite its intravenous application, the impact of DMSO on vascular cells has not been assessed....