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Università della Svizzera italiana

Conformational occlusion of blockade antibody epitopes, a novel mechanism of GII.4 human norovirus immune evasion

Lindesmith, Lisa C. ; Mallory, Michael L. ; Debbink, Kari ; Donaldson, Eric F. ; Brewer-Jensen, Paul D. ; Swann, Excel W. ; Sheahan, Timothy P. ; Graham, Rachel L. ; Beltramello, Martina ; Corti, Davide ; Lanzavecchia, Antonio ; Baric, Ralph S.

In: mSphere, 2018, vol. 3, no. 1, p. e00518-17

Extensive antigenic diversity within the GII.4 genotype of human norovirus is a major driver of pandemic emergence and a significant obstacle to development of cross- protective immunity after natural infection and vaccination. However, human and mouse monoclonal antibody studies indicate that, although rare, antibodies to conserved GII.4 blockade epitopes are generated. The mechanisms by...

Università della Svizzera italiana

Cxcl12 evolution – subfunctionalization of a ligand through altered interaction with the chemokine receptor

Boldajipour, Bijan ; Doitsidou, Maria ; Tarbashevich, Katsiaryna ; Laguri, Cedric ; Yu, Shuizi Rachel ; Ries, Jonas ; Dumstrei, Karin ; Thelen, Sylvia ; Dörries, Julia ; Messerschmidt, Esther-Maria ; Thelen, Marcus ; Schwille, Petra ; Brand, Michael ; Lortat-Jacob, Hugues ; Raz, Erez

In: Development, 2011, vol. 138, no. 14, p. 2909-2914

The active migration of primordial germ cells (PGCs) from their site of specification towards their target is a valuable model for investigating directed cell migration within the complex environment of the developing embryo. In several vertebrates, PGC migration is guided by Cxcl12, a member of the chemokine superfamily. Interestingly, two distinct Cxcl12 paralogs are expressed in zebrafish...

Université de Fribourg

The diversity of population responses to environmental change

Colchero, Fernando ; Jones, Owen R. ; Conde, Dalia A. ; Hodgson, David ; Zajitschek, Felix ; Schmidt, Benedikt R. ; Malo, Aurelio F. ; Alberts, Susan C. ; Becker, Peter H. ; Bouwhuis, Sandra ; Bronikowski, Anne M. ; Vleeschouwer, Kristel M. ; Delahay, Richard J. ; Dummermuth, Stefan ; Fernández‐Duque, Eduardo ; Frisenvænge, John ; Hesselsøe, Martin ; Larson, Sam ; Lemaître, Jean‐François ; McDonald, Jennifer ; Miller, David A.W. ; O'Donnell, Colin ; Packer, Craig ; Raboy, Becky E. ; Reading, Chris J. ; Wapstra, Erik ; Weimerskirch, Henri ; While, Geoffrey M. ; Baudisch, Annette ; Flatt, Thomas ; Coulson, Tim ; Gaillard, Jean‐Michel

In: Ecology Letters, 2019, p. -

The current extinction and climate change crises pressure us to predict population dynamics with ever‐greater accuracy. Although predictions rest on the well‐advanced theory of age‐structured populations, two key issues remain poorly explored. Specifically, how the age‐dependency in demographic rates and the year‐to‐year interactions between survival and fecundity affect...

Consortium of Swiss Academic Libraries

The prevalence of rheumatic diseases in the elderly in developed countries and its evolution over time

Mariller, Marjorie ; Santos-Eggimann, Brigitte

In: Sozial- und Präventivmedizin/Social and Preventive Medicine, 2005, vol. 50, no. 1, p. 45-51

Consortium of Swiss Academic Libraries

Evolutionary choice of markets

Gerber, Anke ; Bettzüge, Marc

In: Economic Theory, 2007, vol. 30, no. 3, p. 453-472

Consortium of Swiss Academic Libraries

SSU rRNA reveals major trends in oomycete evolution

Lara, Enrique ; Belbahri, Lassaad

In: Fungal Diversity, 2011, vol. 49, no. 1, p. 93-100

Consortium of Swiss Academic Libraries

Neuroevolution: from architectures to learning

Floreano, Dario ; Dürr, Peter ; Mattiussi, Claudio

In: Evolutionary Intelligence, 2008, vol. 1, no. 1, p. 47-62