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Università della Svizzera italiana

Conformational dynamics and stability of U-shaped and S-shaped amyloid β assemblies

Grasso, Gianvito ; Rebella, Martina ; Muscat, Stefano ; Morbiducci, Umberto ; Tuszynski, Jack ; Danani, Andrea ; Deriu, Marco A.

In: International journal of molecular sciences, 2018, vol. 19, no. 2, p. 571

Alzheimer’s disease is the most fatal neurodegenerative disorder characterized by the aggregation and deposition of Amyloid β (Aβ) oligomers in the brain of patients. Two principal variants of Aβ exist in humans: Aβ1–40 and Aβ1–42. The former is the most abundant in the plaques, while the latter is the most toxic species and forms fibrils more rapidly. Interestingly, fibrils of...

Consortium of Swiss Academic Libraries

Aggregation and discretization in multistage stochastic programming

Kuhn, Daniel

In: Mathematical Programming, 2008, vol. 113, no. 1, p. 61-94

Université de Fribourg

Structure of β-lactoglobulin microgels formed during heating as revealed by small-angle X-ray scattering and light scattering

Moitzi, Christian ; Donato, Laurence ; Schmitt, Christophe ; Bovetto, Lionel ; Gillies, Graeme ; Stradner, Anna

In: Food Hydrocolloids, 2011, vol. 25, no. 7, p. 1766-1774

We have investigated the structure of microgels formed during heating of demineralized β-lactoglobulin (βlg) solutions at pH 5.9 by small-angle X-ray scattering (SAXS) and light scattering. First, unheated βlg solutions were characterized at different pH values between 2.0 and 7.0. At pH 5.9, βlg solutions contain mainly dimers (with a radius of approx. 2 nm), which coexist with a small...