Université de Fribourg

Effect of intracortical vascular endothelial growth factor infusion and blockade during the critical period in the rat visual cortex

Argandoña, Enrike G. ; Bengoetxea, Harkaitz ; Bulnes, Susana ; Rico-Barrio, Irantzu ; Ortuzar, Naiara ; Lafuente, Jose V.

In: Brain Research, 2012, vol. 1473, p. 141–154

VEGF is the major angiogenic and vascular permeability factor in health and disease. Vascular development depends on function, and in sensory areas is experience-dependent. Our aim was to investigate, qualitatively and quantitatively, the effects of intracortical infusion and neutralisation of VEGF during the first days of the critical visual period, when peak levels of endogenous VEGF secretion...