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Università della Svizzera italiana

Shp-2 is dispensable for establishing T cell exhaustion and for PD-1 signaling in vivo

Rota, Giorgia ; Niogret, Charlène ; Dang, Anh Thu ; Ramon Barros, Cristina ; Fonta, Nicolas Pierre ; Alfei, Francesca ; Morgado, Leonor ; Zehn, Dietmar ; Birchmeier, Walter ; Vivier, Eric ; Guarda, Greta

In: Cell reports, 2018, vol. 23, no. 1, p. 39-49

In chronic infection and cancer, T cells acquire a dysfunctional state characterized by the expression of inhibitory receptors. In vitro studies implicated the phosphatase Shp-2 downstream of these receptors, including PD-1. However, whether Shp-2 is responsible in vivo for such dysfunctional responses remains elusive. To address this, we generated T cell- specific Shp-2-deficient mice. These...

Università della Svizzera italiana

Structural biology of STAT3 and its implications for anticancer therapies development

Sgrignani, Jacopo ; Garofalo, Maura ; Matkovic, Milos ; Merulla, Jessica ; Catapano, Carlo V. ; Cavalli, Andrea

In: International journal of molecular sciences, 2018, vol. 19, no. 6, p. 1591

Transcription factors are proteins able to bind DNA and induce the transcription of specific genes. Consequently, they play a pivotal role in multiple cellular pathways and are frequently over-expressed or dysregulated in cancer. Here, we will focus on a specific “signal transducer and activator of transcription” (STAT3) factor that is involved in several pathologies, including cancer....

Haute école de santé Genève

Accompagnement en fin de vie : promouvoir la qualité de vie auprès d'enfants atteints d'un cancer en phase terminale et de leurs familles : travail de Bachelor

Assouline, Rachel ; Fontanet, Constance ; Fressineau, Manon ; Terraneo, Fabienne (Dir.)

Mémoire de bachelor : Haute école de santé Genève, 2018.

Le but de ce travail est de mettre en évidence les éléments qui pourraient améliorer ou péjorer la qualité de vie d'un enfant atteint de cancer en phase terminale et sa famille, afin de proposer des recommandations de prise en soins pour les infirmières et d'autres professionnels de la santé. Une ébauche de revue de littérature a été effectuée sur PubMed et CINAHL, ce qui a permis de...