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Sprouty proteins, masterminds of receptor tyrosine kinase signaling

Cabrita, Miguel ; Christofori, Gerhard

In: Angiogenesis, 2008, vol. 11, no. 1, p. 53-62

Dynamic conformational transitions of the EGF receptor in living mammalian cells determined by FRET and fluorescence lifetime imaging microscopy

Ziomkiewicz, Iwona ; Loman, Anastasia ; Klement, Reinhard ; Fritsch, Cornelia ; Klymchenko, Andrey S. ; Bunt, Gertrude ; Jovin, Thomas M. ; Arndt-Jovin, Donna J.

In: Cytometry Part A, 2013, vol. 83, no. 9, p. 794–805

We have revealed a reorientation of ectodomain I of the epidermal growth factor receptor (EGFR; ErbB1; Her1) in living CHO cells expressing the receptor, upon binding of the native ligand EGF. The state of the unliganded, nonactivated EGFR was compared to that exhibited after ligand addition in the presence of a kinase inhibitor that prevents endocytosis but does not interfere with binding or the...