Université de Fribourg

Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis

Buschmann, Ivo ; Pries, Axel ; Styp-Rekowska, Beata ; Hillmeister, Philipp ; Loufrani, Laurent ; Henrion, Daniel ; Shi, Yu ; Duelsner, Andre ; Hoefer, Imo ; Gatzke, Nora ; Wang, Haitao ; Lehmann, Kerstin ; Ulm, Lena ; Ritter, Zully ; Hauff, Peter ; Hlushchuk, Ruslan ; Djonov, Valentin ; Veen, Toon van ; Noble, Ferdinand le

In: Development, 2010, vol. 137, p. 2187-2196

In the developing chicken embryo yolk sac vasculature, the expression of arterial identity genes requires arterial hemodynamic conditions. We hypothesize that arterial flow must provide a unique signal that is relevant for supporting arterial identity gene expression and is absent in veins. We analyzed factors related to flow, pressure and oxygenation in the chicken embryo vitelline vasculature...