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Università della Svizzera italiana

The prospect and challenges to the flow of liquid biopsy in Africa

Oluwaseyi Temilola, Dada ; Wium, Martha ; Coulidiati, Tangbadioa Herve ; Adeola, Henry Ademola ; Carbone, Giuseppina Maria ; Catapano, Carlo Vittorio Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland ; Zerbini, Luiz Fernando

In: Cells, 2019, vol. 8, no. 8, p. 862

Liquid biopsy technologies have the potential to transform cancer patient management as it others non- invasive diagnosis and real-time monitoring of disease progression and treatment responses. The use of liquid biopsy for non-invasive cancer diagnosis can have pivotal importance for the African continent where access to medical infrastructures is limited, as it eliminates the need for...

Università della Svizzera italiana

SHP-2 in lymphocytes’ cytokine and inhibitory receptor signaling

Niogret, Charlène ; Birchmeier, Walter ; Guarda, Greta

In: Frontiers in immunology, 2019, vol. 10, no. 2468, p. 1-11

Somewhat counterintuitively, the tyrosine phosphatase SHP-2 (SH2 domain- containing protein tyrosine phosphatase-2) is crucial for the activation of extracellular signal-regulated kinase (ERK) downstream of various growth factor receptors, thereby exerting essential developmental functions. This phosphatase also deploys proto-oncogenic functions and specific inhibitors have recently been ...

Haute école de santé Genève

Les besoins des adolescents atteints d'une pathologie cancéreuse et de sa famille : travail de Bachelor

Gomes Costa Vaz, Diana ; Gonçalves Da Rosa, Marina ; Lopes Cunha, Monica ; Terraneo, Fabienne (Dir.)

Mémoire de bachelor : Haute école de santé Genève, 2019.

Le cancer est un problème de santé majeur. D'autant plus, lorsqu'il touche une population comme les adolescents. En pleine transition, le jeune ainsi que sa famille font face à de multiples changements. Vient s'ajouter à cela une pathologie oncologique, qui va venir bouleverser leur quotidien déjà bien turbulent. Ces éléments ont soulevé une première question de recherche "Quelles sont...

Haute Ecole Arc Santé

Chez les femmes de plus de cinquante ans atteintes de cancer du sein, quel est l'impact de la méditation pleine conscience sur la gestion du stress et le bien-être ?

Biedert, Stéphanie ; Candolfi, Alison ; Eusebe Kübler, Pamela ; Graber, Myriam (Dir.)

Mémoire de bachelor : Haute Ecole Arc Santé, 2019.

Ce travail de Bachelor va permettre d’identifier les effets de la méditation pleine conscience sur la gestion du stress et sur la capacité de cette intervention à agir sur la qualité de vie des femmes de cinquante ans et plus, atteintes de cancer du sein.

Università della Svizzera italiana

Shp-2 is dispensable for establishing T cell exhaustion and for PD-1 signaling in vivo

Rota, Giorgia ; Niogret, Charlène ; Dang, Anh Thu ; Ramon Barros, Cristina ; Fonta, Nicolas Pierre ; Alfei, Francesca ; Morgado, Leonor ; Zehn, Dietmar ; Birchmeier, Walter ; Vivier, Eric ; Guarda, Greta

In: Cell reports, 2018, vol. 23, no. 1, p. 39-49

In chronic infection and cancer, T cells acquire a dysfunctional state characterized by the expression of inhibitory receptors. In vitro studies implicated the phosphatase Shp-2 downstream of these receptors, including PD-1. However, whether Shp-2 is responsible in vivo for such dysfunctional responses remains elusive. To address this, we generated T cell- specific Shp-2-deficient mice. These...

Università della Svizzera italiana

Structural biology of STAT3 and its implications for anticancer therapies development

Sgrignani, Jacopo ; Garofalo, Maura ; Matkovic, Milos ; Merulla, Jessica ; Catapano, Carlo V. ; Cavalli, Andrea

In: International journal of molecular sciences, 2018, vol. 19, no. 6, p. 1591

Transcription factors are proteins able to bind DNA and induce the transcription of specific genes. Consequently, they play a pivotal role in multiple cellular pathways and are frequently over-expressed or dysregulated in cancer. Here, we will focus on a specific “signal transducer and activator of transcription” (STAT3) factor that is involved in several pathologies, including cancer....