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The novel TORC1/2 kinase inhibitor PQR620 has anti-tumor activity in lymphomas as a single agent and in combination with venetoclax

Tarantelli, Chiara ; Gaudio, Eugenio ; Hillmann, Petra ; Spriano, Filippo ; Sartori, Giulio ; Aresu, Luca ; Cascione, Luciano ; Rageot, Denise ; Kwee, Ivo ; Beaufils, Florent ; Zucca, Emanuele ; Stathis, Anastasios ; Wymann, Matthias P. ; Cmiljanovic, Vladimir ; Fabbro, Doriano ; Bertoni, Francesco

In: Cancers, 2019, vol. 11, no. 6, p. 775

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling cascade is an important therapeutic target for lymphomas. Rapamycin-derivates as allosteric mTOR complex 1 (TORC1) inhibitors have shown moderate preclinical and clinical anti-lymphoma activity. Here, we assessed the anti-tumor activity of PQR620, a novel brain penetrant dual TORC1/2 inhibitor, in 56...

Selective In Vivo and In Vitro Effects of a Small Molecule Inhibitor of Cyclin-Dependent Kinase 4

Soni, Rajeev ; O'Reilly, Terence ; Furet, Pascal ; Muller, Lionel ; Stephan, Christine ; Zumstein-Mecker, Sabine ; Fretz, Heinz ; Fabbro, Doriano ; Chaudhuri, Bhabatosh

In: Journal of the National Cancer Institute, 2001, vol. 93, no. 6, p. 436-446

Induction of Apoptosis in Small-Cell Lung Cancer Cells by an Antisense Oligodeoxynucleotide Targeting the Bcl-2 Coding Sequence

Ziegler, Annemarie ; Luedke, Gerd H. ; Stahel, Rolf A. ; Zangemeister-Wittke, Uwe ; Fabbro, Doriano ; Altmann, Karl-Heinz

In: Journal of the National Cancer Institute, 1997, vol. 89, no. 14, p. 1027-1036