Université de Fribourg

Hard sphere-like glass transition in eye lens α-crystallin solutions

Foffi, Giuseppe ; Savin, Gabriela ; Bucciarelli, Saskia ; Dorsaz, Nicolas ; Thurston, George M. ; Stradner, Anna ; Schurtenberger, Peter

In: Proceedings of the National Academy of Sciences, 2014, vol. 111, no. 47, p. 16748–16753

We study the equilibrium liquid structure and dynamics of dilute and concentrated bovine eye lens α-crystallin solutions, using small-angle X-ray scattering, static and dynamic light scattering, viscometry, molecular dynamics simulations, and mode-coupling theory. We find that a polydisperse Percus–Yevick hard-sphere liquid-structure model accurately reproduces both static light scattering...

Université de Fribourg

Cluster-Driven dynamical arrest in concentrated lysozyme solutions

Cardinaux, Frédéric ; Zaccarelli, Emanuela ; Stradner, Anna ; Bucciarelli, Saskia ; Farago, Bela ; Egelhaaf, Stefan U. ; Sciortino, Francesco ; Schurtenberger, Peter

In: The Journal of Physical Chemistry B, 2011, vol. 115, no. 22, p. 7227–7237

We present a detailed experimental and numerical study of the structural and dynamical properties of salt-free lysozyme solutions. In particular, by combining small-angle X-ray scattering (SAXS) data with neutron spin echo (NSE) and rheology experiments, we are able to identify that an arrest transition takes place at intermediate densities, driven by the slowing down of the cluster motion. Using...